Chemical Name Ranolazine-d8
Alternate Names Ranolazine Stable Isotopes, Stable Isotopes of Ranolazine
CAT No. CS-O-10474
CAS Registry# 1092804-88-0
Category Stable Isotopes
Stock IN-Stock
Mol. Wt. 435.59 g/mol
Mol. For. C₂₄H₂₅D₈N₃O₄
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Ranolazine
Purity 95%
Smileys OC(CN1C([2H])([2H])C([2H])([2H])N(CC(NC(C(C)=CC=C2)=C2C)=O)C([2H])([2H])C1([2H])[2H])COC(C=CC=C3)=C3OC
Canonical Smiles CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
Inchl InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)/i11D2,12D2,13D2,14D2
IUPAC N-(2,6-dimethylphenyl)-2-[2,2,3,3,5,5,6,6-octadeuterio-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
Controlled No
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Ranolazine-d8 is a deuterated analog of ranolazine, a medication used for the treatment of chronic angina pectoris. It is a selective inhibitor of the late sodium current in cardiomyocytes, which reduces intracellular calcium overload and improves myocardial relaxation. Ranolazine-d8 can be used for pharmacokinetic studies and quantitative analysis in biological samples. Chemically, ranolazine-d8 is a white to off-white crystalline powder with a molecular weight of 415.6 g/mol. It is soluble in water and ethanol, and has a melting point of 166-168°C. The deuterium substitution at the eight position of the ranolazine molecule can be detected by mass spectrometry and nuclear magnetic resonance spectroscopy, which allows for precise identification and quantification. Ranolazine-d8 is typically administered orally, with a recommended starting dose of 500 mg twice daily. It is metabolized by the liver and excreted in the urine, with a half-life of approximately 7 hours. Due to its potential interactions with other medications and conditions, it is important to consult with a healthcare provider before taking ranolazine-d8. Overall, ranolazine-d8 is a useful tool for researchers studying the pharmacokinetics and effects of ranolazine in the body. Its deuterium substitution allows for sensitive and accurate analysis, which can aid in the development of new treatments for angina and other cardiovascular conditions.

Related Compounds

Desmethoxy Ranolazine-d5 | Ranolazine D8 Hydrochloride | Ranolazine D3 | Ranolazine D3 HCl |

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