SN-38-d3
| Product Name | SN-38-d3 |
|---|---|
| CAT No. | CS-T-85120 |
| CAS No. | 718612-49-8 |
| Category | Stable Isotopes |
| Stock | Enquire |
| Mol. Wt. | 395.42 g/mol |
| Mol. For. | C₂₂H₁₇D₃N₂O₅ |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Smileys | O=C1C(COC(C2(O)CC)=O)=C2C=C3N1CC4=C3N=C5C=CC(O)=CC5=C4CC([2H])([2H])[2H] |
| Canonical Smiles | CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)O |
| InchIKey | FJHBVJOVLFPMQE-MVTYLIICSA-N |
| Inchl | InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1/i1D3 |
| IUPAC | (19S)-19-ethyl-7,19-dihydroxy-10-(2,2,2-trideuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
SN-38-d3 is a deuterium-labeled analogue of SN-38, which is a potent antineoplastic agent used in the treatment of various types of cancer. SN-38-d3 is used in pharmacokinetic studies to study the metabolism and disposition of SN-38 in vivo, as well as to assess the efficacy and safety of chemotherapeutic agents that contain SN-38 as an active ingredient.
SN-38-d3 is a derivative of irinotecan, which is a prodrug that is metabolized to SN-38 in vivo. The deuterium label on SN-38-d3 allows for accurate quantification of the drug in biological samples using mass spectrometry. This is important for determining the pharmacokinetic parameters of SN-38, such as its absorption, distribution, metabolism, and elimination from the body.
The chemical structure of SN-38-d3 is similar to that of SN-38, with the only difference being the presence of deuterium atoms at specific positions in the molecule. SN-38-d3 is a potent inhibitor of topoisomerase I, which is an enzyme involved in DNA replication and repair. By inhibiting topoisomerase I, SN-38-d3 prevents DNA from being properly replicated and repaired, leading to cell death.
In conclusion, SN-38-d3 is a valuable tool for studying the pharmacokinetics and pharmacodynamics of SN-38 and for developing more effective and safer chemotherapeutic agents for cancer treatment.
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