Sofosbuvir 3’,5’-Bis-(S)-phosphate

Product Name Sofosbuvir 3’,5’-Bis-(S)-phosphate
Alternate Names Sofosbuvir Impurities, Impurities of Sofosbuvir
CAT No. CS-T-84999
CAS No. 1337482-17-3
Category Impurities
Stock IN-Stock
Mol. Wt. 798.69 g/mol
Mol. For. C₃₄H₄₅FN₄O₁₃P₂
Hazardous This is not a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Sofosbuvir
Therapeutic Antiretroviral / Anti-HIV
Smileys C[C@H](NP(OC1=CC=CC=C1)(O[C@@H]2[C@@H](COP(OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)O[C@@H](N(C(N4)=O)C=CC4=O)[C@@]2(F)C)=O)C(OC(C)C)=O
Canonical Smiles CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)OP(=O)(NC(C)C(=O)OC(C)C)OC3=CC=CC=C3)OC4=CC=CC=C4
InchIKey WVORGVRHMQFKTN-ACVYKXDBSA-N
Inchl InChI=1S/C34H45FN4O13P2/c1-21(2)47-30(41)23(5)37-53(44,50-25-14-10-8-11-15-25)46-20-27-29(34(7,35)32(49-27)39-19-18-28(40)36-33(39)43)52-54(45,51-26-16-12-9-13-17-26)38-24(6)31(42)48-22(3)4/h8-19,21-24,27,29,32H,20H2,1-7H3,(H,37,44)(H,38,45)(H,36,40,43)/t23-,24-,27+,29+,32+,34+,53?,54?/m0/s1
IUPAC propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyl-3-[[[(2S)-1-oxo-1-propan-2-yloxypropan-2-yl]amino]-phenoxyphosphoryl]oxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
Controlled No
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Sofosbuvir 3’,5’-Bis-(S)-phosphate is a prodrug of Sofosbuvir, which is a potent inhibitor of the hepatitis C virus (HCV) polymerase enzyme. Sofosbuvir has revolutionized the treatment of HCV, which affects millions of people worldwide. The drug is generally well-tolerated and has high efficacy rates in curing HCV infections. Sofosbuvir 3’,5’-Bis-(S)-phosphate is a phosphorylated form of Sofosbuvir, which increases its solubility and bioavailability. It is rapidly converted to Sofosbuvir in the body and the active drug is then able to enter hepatocytes and inhibit the replication of HCV. Sofosbuvir 3’,5’-Bis-(S)-phosphate has shown to be effective against all genotypes of HCV and has minimal side effects. The chemical structure of Sofosbuvir 3’,5’-Bis-(S)-phosphate includes a phosphorus atom, which is essential for its activity. The drug works by inhibiting the HCV RNA polymerase enzyme, which is crucial for the replication of the virus. It acts as a nucleotide analogue, which means it can mimic the building blocks of RNA and interfere with the replication process. In conclusion, Sofosbuvir 3’,5’-Bis-(S)-phosphate is a prodrug of the highly effective HCV inhibitor Sofosbuvir. Its phosphorylation increases its solubility and bioavailability and it works by inhibiting the HCV RNA polymerase enzyme. The drug has revolutionized the treatment of HCV and has high efficacy rates with minimal side effects.

Related Compounds

Sofosbuvir impurity 3 | Sofosbuvir Dimer | Ethyl sofosbuvir | Sofosbuvir impurity 32 | Sofosbuvir L-alanitate (Mixture of Diasteriomers) | N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine-1-methylethyl ester | O-Desphenyl Sofosbuvir | Sofosbuvir impurity 6 | Sofosbuvir impurity 43 | Ethyl 2-(triphenylphosphoranylidene)propanoate | Sofosbuvir Chloro Analogue | Sofosbuvir impurity 12 | Sofosbuvir impurity 9 | Sofosbuvir impurity 5 | Sofosbuvir Des L-​Alanine | Chloro Sofosbuvir Desphosphate | Sofosbuvir intermediate isomer Impurity | L-Alanine Isopropyl Ester Hydrochloride | Chloro (R)-Phosphoryl Sofosbuvir | Sofosbuvir Degradation Impurity 1 | Sofosbuvir Impurity | Sofosbuvir Impurity 11 | Sofosbuvir impurity 19 | Sofosbuvir Impurity D | Sofosbuvir D-Alaninate | Isopropyl N-[chloro(phenoxy)phosphoryl]-L-alaninate |

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