Product Detail
Eplerenone
Eplerenone API
Stock Status: In Stock
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For Research & Analytical Purposes. Not for Personal use.
Category
API
API Family
Eplerenone
Storage
Store at refrigerator (2-8°C) for long term storage
Hazard Information
Refer MSDS for complete information.
Eplerenone Product Information
Eplerenone is listed under API. It is associated with Eplerenone and is intended for analytical research, quality control and pharmaceutical reference standard applications. The product is supplied by Clearsynth under CAT No. CS-O-01427.
Clearsynth provides this compound for research and analytical use, with product information including CAS number, molecular formula, molecular weight, stock enquiry details and supporting documentation.
Technical Data
Product Name
Eplerenone
CAS No.
107724-20-9
CAT No.
CS-O-01427
Molecular Formula
C₂₄H₃₀O₆
Molecular Weight
414.49
Category
API Family
Storage Condition
Store at refrigerator (2-8°C) for long term storage
SMILES
O=C1C=C(C[C@@]2([H])C(OC)=O)[C@@](CC1)(C)[C@]34[C@]2([H])[C@@](CC[C@@]5(O6)CCC6=O)([H])[C@]5(C)C[C@@]3([H])O4
IUPAC Name
(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-methyl
4a,6a-dimethyl-2,5'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[
cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
Purity by HPLC
Not less than 95%
Hazard Compound
Refer MSDS for complete information.
Description
Overview
"Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors."
Synonyms
Not Available
Application Notes
"Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors."
References
"De Gasparo et al (1987) Three new epoxy-spirolctone derivatives:charcterization in vivo and in vitro, J,Pharmcol,Exp,Ther, 240 650, cMahon (2001) Rcent studies with eplerenone; a novel selctive aldosterone rceptor antagonist,curr,Opin,Pharmcol, 1 190,"
