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Pazopanib hydrochloride

ISO 17034:
Catalog Number : CS-CW-00177
CAS Number : 635702-64-6
Status : Available for immediate dispatch
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Chemical Information

Chemical Name : Pazopanib hydrochloride
Category : API Standards
Purity : Not less than 90%
Synonyms : Not available
Molecular Weight : 473.98 mol/g
Molecular Formula : C₂₁H₂₄CIN₇O₂S
Application : "A potent and selective inhibitor of tyrosine kinases, targeting VEGFR/c-KIT/PDGFR, blocking angiogenesis; as an oral antineoplastic agent"
Therapeutic : Anti-Cancer / Oncology

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Hazardous Compound : No

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Additional Information

Canonical SMILES : CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
Isomeric SMILES : CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
InChI : InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
IUPAC Name : 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride
Exact Mass : 473.1400719
Use Classification : Human drugs -> Votrient -> EMA Drug Category
Hazard Class : Carc. 2 (25%)
Description : Pazopanib hydrochloride is a hydrochloride salt prepared from equimolar amounts of pazopanib and hydrochloric acid. Used for treatment of kidney cancer. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, a tyrosine kinase inhibitor and an angiogenesis modulating agent. It contains a pazopanib(1+).
EC Number : 619-728-0

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