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Diphenhydramine-N-oxide hydrochloride

ISO 17034:
Catalog Number : CS-DH-00007
CAS Number : 13168-00-8
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What is the Chemical Information of Diphenhydramine-N-oxide hydrochloride?

Chemical Name : Diphenhydramine-N-oxide hydrochloride
Category : Metabolites
Therapeutic : Antihistamine

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Diphenhydramine (DPH) is an antihistamine medication mainly used to treat allergies. It can also be used for insomnia, symptoms of the common cold, tremor in parkinsonism, and nausea. It is taken by mouth, injected into a vein, injected into a muscle, or applied to the skin. Maximal effect is typically around two hours after a dose, and effects can last for up to seven hours.Common side effects include sleepiness, poor coordination and an upset stomach. Its use is not recommended in young children or the elderly. There is no clear risk of harm when used during pregnancy; however, use during breastfeeding is not recommended. It is a first generation H1-antihistamine and ethanolamine and works by blocking certain effects of histamine. Diphenhydramine is also a potent anticholinergic, and works as a deliriant at higher than recommended doses as a result. This has led to some cases of recreational use and addiction.Diphenhydramine was first made by George Rieveschl and came into commercial use in 1946. It is available as a generic medication. It is sold under the brand name Benadryl, among others. In 2017, it was the 241st most commonly prescribed medication in the United States, with more than two million prescriptions.
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What are the Metabolites of Diphenhydramine ?

CS-P-09004 Diphenhydramine N-Glucuronide 137908-78-2 Diphenhydramine Glucuronides
CS-O-41341 N-Nitroso N-Desmethyl Diphenhydramine-D5 - Diphenhydramine Stable Isotopes
CS-O-38640 N-Nitroso N-Desmethyl Diphenhydramine 55855-43-1 Diphenhydramine Impurities
CS-EB-00686 Diphenhydramine Related Compound A Diphenhydramine Impurities
CS-ED-01727 Diphenhydramine-d6 Hydrochloride 1189986-72-8 Diphenhydramine Stable Isotopes
CS-T-93423 Diphenhydramine 58-73-1 Diphenhydramine API Standards
CS-O-30428 Diphenhydramine Impurity K 574-42-5 Diphenhydramine Impurities
CS-T-88964 N-Desmethyl Diphenhydramine-d3 Hydrochloride 1794759-12-8 Diphenhydramine Stable Isotopes
CS-CY-00074 Diphenhydramine Impurity D 91-01-0 Diphenhydramine Impurities
CS-P-08287 Diphenhydramine D5 NA Diphenhydramine Stable Isotopes
CS-EB-02396 Diphenhydramine Hydrochloride (1218005) 147-24-0 Diphenhydramine USP Standards
CS-CY-00018 Diphenhydramine Impurity B 4024-34-4 Diphenhydramine Impurities
CS-T-20855 Diphenhydramine Citrate 88637-37-0 Diphenhydramine Intermediates
CS-ER-00652 Diphenhydramine Related Compound A(Secondary Standards traceble to USP) 53499-40-4 Diphenhydramine Secondary Standards
CS-O-11820 Diphenhydramine N-Oxide 3922-74-5 Diphenhydramine Metabolites
CS-O-06550 Diphenhydramine D5 Hydrochloride 1219795-16-0 Diphenhydramine Stable Isotopes
CS-ER-00277 Bromodiphenhydramine Hydrochloride(Secondary Standards traceble to USP) 1808-12-4 Diphenhydramine Secondary Standards
CS-O-34805 N-acetyl N-desmethyldiphenhydramine 109881-19-8 Diphenhydramine Metabolites
CS-O-30389 Diphenhydramine impurity C 1808-12-4 Diphenhydramine Impurities
CS-O-36072 Diphenhydramine Quaternary Salt 857158-22-6 Diphenhydramine Fine Chemicals
CS-EB-00687 Diphenhydramine Related Compound B (F016V0) 19574-66-4 Diphenhydramine USP Standards
CS-O-10860 Diphenhydramine Hydrochloride 147-24-0 Diphenhydramine API Standards
CS-M-53270 Diphenhydramine Impurity A 53499-40-4 Diphenhydramine Impurities