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Fluticasone Propionate



Chemical Properties of 'Fluticasone Propionate'

CAT No. :

CS-O-00625
CAS Registry No. : 80474-14-2
Category : API Standards
Molecular Weight: 500.57
Molecular Formula : C₂₅H₃₁F₃O₅S



OTHER INFORMATION of 'Fluticasone Propionate'
Purity : Not less than 95 %
Therapeutic : Anti-Asthma / COPD
IUPAC Name :[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Applicationnotes :A derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory.
Synonym :Not available
References :"DeWester; J,; et al,: Allergy Asthma Prc,; 24; 331 (2003);"
Smileys :CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
Appearance :White to off white solid
Melting Point :261-273 °C
Solubility :Insoluble
Use Classification :Human Drugs -> EU pediatric investigation plans
EC Number :617-082-4
UNII :O2GMZ0LF5W
NCI Thesaurus Code :C29061
RXCUI :50121
MeSH Entry Terms :Cutivate
Other Synonyms :FLUTICASONE PROPIONATE
Removed Synonyms :fluticasone
Label Ingredient : AZELASTINE HYDROCHLORIDE; FLUTICASONE PROPIONATE
NDC Code :0037-0245-06, 0037-0245-23, 0054-0293-99, 0378-3458-23, 17478-718-10, 42291-094-30, 45802-026-83, 45802-066-01, 47335-779-91, 47335-938-90 ... total 43.
Toxicity Summary :Fluticasone propionate's use in specific populations has not been well studied. Fluticasone propionate is not carcinogenic, mutagenic, or clastogenic, nor did it affect fertility in animal studies. Subcutaneous fluticasone propionate has been shown to produce teratogenic effects in rats though oral administration does not. Generally, there are no reported adverse effects with fluticasone in pregnancy. Fluticasone propionate in human milk may cause growth suppression, effects on endogenous corticosteroid production, or other effects. Pediatric patients treated with fluticasone propionate ointment experienced adrenal suppression. Geriatric patients treated with fluticasone propionate did not show any difference in safety or efficacy compared to other patient groups, though older patients may be more sensitive to adverse effects. There is no difference in the clearance of fluticasone propionate across genders or race. Patients with hepatic impairment should be closely monitored due to the elimination mechanism.
Protein Binding :Fluticasone propionate is 99% protein bound in serum. Topical fluticasone propionate is only 91% protein bound in serum however.
Exact Mass :500.18442974
InChI :InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
InchIKey :WMWTYOKRWGGJOA-CENSZEJFSA-N
Canonical SMILES :CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
Isomeric SMILES :CCC(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)SCF
Product Description :Fluticasone propionate is a trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity. It has a role as an anti-allergic agent, an anti-asthmatic drug, an anti-inflammatory drug, a dermatologic drug, a bronchodilator agent and an adrenergic agent. It is a corticosteroid, a steroid ester, an 11beta-hydroxy steroid, a propanoate ester, a fluorinated steroid, a thioester and a 3-oxo-Delta(1),Delta(4)-steroid. It derives from a fluticasone. It derives from a hydride of an androstane.
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 18-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 18-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back


More information about Fluticasone


Fluticasone is a manufactured glucocorticoid used to treat nasal symptoms. Both the esters, fluticasone furoate and fluticasone propionate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.

The route of administration varies, but often it is inhaled intranasally. It may use an exhalation delivery system.

It is on the World Health Organization's List of Essential Medicines. In 2019, it was the eighteenth most commonly prescribed medication in the United States, with more than 27\u00a0million prescriptions.


See also




This page contains information about Fluticasone Propionate , Fluticasone Propionate cas, Fluticasone Propionate synthesis, Fluticasone Propionate suppliers

What is Fluticasone Propionate ?
Fluticasone Propionate falls under API Standards of Fluticasone.A derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory.
What is the CAS Number of Fluticasone Propionate?
The CAS Number of Fluticasone Propionate is 80474-14-2
Who are the suppliers of Fluticasone Propionate?
CLEARSYNTH is a worldwide supplier of Fluticasone Propionate

Related compounds of Fluticasone Propionate

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