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Clofarabine



Chemical Properties of 'Clofarabine'

CAT No. :

CS-O-01201
CAS Registry No. : 123318-82-1
Category : API Standards
Molecular Weight: 303.68
Molecular Formula : C₁₀H₁₁ClFN₅O₃



OTHER INFORMATION of 'Clofarabine'
Purity : Not less than 95%
Therapeutic : Anti-Cancer / Oncology
Purity : Not less than 95%
Therapeutic : Anti-Cancer / Oncology
IUPAC Name :(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Applicationnotes :Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
Synonym :Not available
References :"Gandhi; V,; et al,:clin,cacer Res,; 9; 6335 (2003); Kantarjian; H,; et al,: Blood; 102; 2379 (2003); Faderl; S,; et al,:cacer; 103; 1985 (2005);"
Smileys :NC1=C(N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F)C2=NC(Cl)=N1
Appearance :White to off white solid
Solubility :4.89e+00 g/L
Use Classification :Human drugs -> Evoltra -> EMA Drug Category
Hazard Class :Acute Tox. 2 (84.78%)
EC Number :631-422-9
UNII :762RDY0Y2H
NCI Thesaurus Code :C26638
RXCUI :44151
MeSH Entry Terms :2 Chloro 2' arabino fluoro 2' deoxyadenosine
Other Synonyms :Clofarabine
Removed Synonyms :ivozall
Label Ingredient : CLOFARABINE
NDC Code :0024-5860-01, 0955-1746-01, 16729-431-05, 43598-309-20, 49315-003-06, 60505-6166-0, 63323-572-70, 67457-546-20, 68083-386-01, 70121-1236-1, 71288-128-20, 72266-108-01
Toxicity Summary :There were no known overdoses of clofarabine. The highest daily dose administered to a human to date (on a mg/m2 basis) has been 70 mg/m2/day × 5 days (2 pediatric ALL patients). The toxicities included in these 2 patients included grade 4 hyperbilirubinemia, grade 2 and 3 vomiting, and grade 3 maculopapular rash.
Hepatotoxicity :In clinical trials, serum enzymes elevations occurred in up to 75% of patients treated with clofarabine as monotherapy for refractory or relapsed acute leukemia. These elevations usually arose within 5 to 10 days of starting therapy and were generally transient and asymptomatic. The elevations rarely required dose adjustment or delay in therapy. Cases of clinically apparent liver injury due to clofarabine have been reported to occur, but few details were available and most patients were receiving other cancer chemotherapeutic agents. A single case report of toxic epidermal necrosis and fulminant hepatic failure in a child with ALL receiving clofarabine has been published. In high doses, clofarabine has been associated with very high rates of serum enzyme elevations and hyperbilirubinemia that are dose limiting. Instances of capillary leak syndrome and possibly sinusoidal obstruction syndrome have also been reported.
Drug Induced Liver Injury :clofarabine
Protein Binding :47% bound to plasma proteins, predominantly to albumin.
Exact Mass :303.0534451
InChI :InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InchIKey :WDDPHFBMKLOVOX-AYQXTPAHSA-N
Canonical SMILES :C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)F)Cl)N
Isomeric SMILES :C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N
Product Description :Clofarabine is a purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. It has a role as an antineoplastic agent and an antimetabolite. It is an organofluorine compound and a member of adenosines.
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 15-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 15-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back


More information about Clofarabine






This page contains information about Clofarabine , Clofarabine cas, Clofarabine synthesis, Clofarabine suppliers

What is Clofarabine ?
Clofarabine falls under API Standards of Clofarabine.Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
What is the CAS Number of Clofarabine?
The CAS Number of Clofarabine is 123318-82-1
Who are the suppliers of Clofarabine?
CLEARSYNTH is a worldwide supplier of Clofarabine

List of Clofarabine API Standards

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