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Cobicistat



Chemical Properties of 'Cobicistat'

CAT No. :

CS-O-01242
CAS Registry No. : 1004316-88-4
Category : API Standards
Molecular Weight: 776.02
Molecular Formula : C₄₀H₅₃N₇O₅S₂



OTHER INFORMATION of 'Cobicistat'
Purity : Not less than 95 %
Therapeutic : Synthetic Peptides
Purity : Not less than 95 %
Therapeutic : Synthetic Peptides
IUPAC Name :1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
Applicationnotes :"Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir as a pharmacoenhancer, significantly increasing their plasma concentrations."
Synonym :Not available
References :"Von; H,; Exp, Rev,clin, Pharmcol,; 5; 557 (2012); Lepist; E,I,; et al,: Antimcrob, Agent,chemother,; 56; 5409 (2012); Orr; S,T,M,; et al,: J, Med,chem,; 55; 4896 (2012);"
Smileys :O=C([C@@H](NC(N(C)CC1=CSC(C(C)C)=N1)=O)CCN2CCOCC2)N[C@H](CC[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4)CC5=CC=CC=C5
Appearance :Pale yellow to yellow solid
Use Classification :Human drugs -> Tybost -> EMA Drug Category
UNII :LW2E03M5PG
NCI Thesaurus Code :C97360
RXCUI :1306284
MeSH Entry Terms :9350, GS
Other Synonyms :Cobicistat
Removed Synonyms :?Cobicistat
Label Ingredient : ATAZANAVIR SULFATE; COBICISTAT
NDC Code :0003-3622-12, 0003-3624-12, 0003-3631-12, 0003-3638-10, 0003-3641-11, 0093-5526-06, 0093-5527-06, 0093-5528-56, 0904-6875-04, 16714-860-01 ... total 85.
Toxicity Summary :The most common adverse reactions reported during clinical trials were jaundice (13%), ocular icterus (15%), and nausea (12%).
Protein Binding :97-98% bound to human plasma proteins.
Exact Mass :775.35496016
InChI :InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1
InchIKey :ZCIGNRJZKPOIKD-CQXVEOKZSA-N
Canonical SMILES :CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
Isomeric SMILES :CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
Product Description :Cobicistat is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoic acid with the amino group of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate. Acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications.. It has a role as a P450 inhibitor. It is a member of 1,3-thiazoles, a member of morpholines, a member of ureas, a carbamate ester and a monocarboxylic acid amide.
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 2-3 Weeks
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 2-3 Weeks
Taxes : Not Applicable
Refund Policy : 30-days money back


More information about Cobicistat


Cobicistat, sold under the brand name Tybost, is a medication for use in the treatment of human immunodeficiency virus infection (HIV/AIDS). Its major mechanism of action is through the inhibition of human CYP3A proteins.

Like ritonavir (Norvir), cobicistat is of interest for its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor. By combining cobicistat with elvitegravir, higher concentrations of the latter are achieved in the body with lower dosing, theoretically enhancing elvitegravir's viral suppression while diminishing its adverse side-effects. In contrast with ritonavir, the only other booster approved for use as a part of HAART, cobicistat has no anti-HIV activity of its own.

Cobicistat is a component of three four-drug, fixed-dose combination HIV treatments. The first, elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil, is marketed as Stribild and was approved by the FDA in August 2012 for use in the United States. The second, elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide, is marketed as Genvoya and was approved by the FDA in November 2015 for use in the United States. Both Stribild and Genvoya are owned by Gilead Sciences. The third, cobicistat, darunavir, emtricitabine, and tenofovir alafenamide, is marketed as Symtuza and was FDA approved July 17, 2018 and is owned by Janssen Pharmaceuticals.

Additionally, in existence are a fixed-dose combination of cobicistat and protease inhibitor darunavir (darunavir/cobicistat; marketed as Prezcobix by Janssen Therapeutics), and a fixed-dose combination of cobicistat and protease inhibitor atazanavir (atazanavir/cobicistat; marketed as Evotaz by Bristol-Myers Squibb). Both Prezcobix and Evotaz were approved by the FDA in January 2015.

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir, and tenofovir alafenamide.




This page contains information about Cobicistat , Cobicistat cas, Cobicistat synthesis, Cobicistat suppliers

What is Cobicistat ?
Cobicistat falls under API Standards of Cobicistat."Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir as a pharmacoenhancer, significantly increasing their plasma concentrations."
What is the CAS Number of Cobicistat?
The CAS Number of Cobicistat is 1004316-88-4
Who are the suppliers of Cobicistat?
CLEARSYNTH is a worldwide supplier of Cobicistat

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