Fingolimod

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Catalog Number : CS-O-01552
CAS Number : 162359-55-9
Status : Available for immediate dispatch
Category : API Standards
Purity : Not less than 95%
Molecular Weight : 307.47 mol/g
Molecular Formula : C₁₉H₃₃NO₂
Therapeutic : Immunosuppressants
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Status : Available for immediate dispatch
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Hazardous Compound : Yes

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Application : Fingolimod is a sphingosine-derivative and IMMUNOSUPPRESSIVE AGENT that blocks the migration and homing of LYMPHOCYTES to the CENTRAL NERVOUS SYSTEM through its action on SPHINGOSINE 1-PHOSPHATE RECEPTORS. It is used in the treatment of MULTIPLE SCLEROSIS??
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Taxes : All prices are inclusive taxes
Refund Policy : 30 days money back guarantee
Canonical SMILES : CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
Isomeric SMILES : CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
InChI : InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
InchIKey : KKGQTZUTZRNORY-UHFFFAOYSA-N
IUPAC Name : 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
Exact Mass : 307.251129295
Melting Point : 102-107
Solubility : Soluble
Use Classification : Human drugs -> Gilenya -> EMA Drug Category
Description : Fingolimod is an aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimod is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate. It has a role as an immunosuppressive agent, a prodrug, an antineoplastic agent, a sphingosine-1-phosphate receptor agonist and a CB1 receptor antagonist. It is an aminodiol and a primary amino compound. It is a conjugate base of a fingolimod(1+).
Toxicity Summary : The LD50 of fingolimod in rats ranges from 300-600 mg/kg. Prescribing information for fingolimod does not mention symptoms or management of an overdose, however, a case report of an intentional overdose with 14mg of fingolimod and 2g phenoxymethylpenicillin resulted in hypotension in bradycardia, resolved by administering atropine. Since fingolimod has been associated with cardiotoxicity, it would be reasonable to expect cardiac effects such as bradycardia and heart block in the case of an overdose.

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