ISO 17034:
Catalog Number : CS-O-01580
CAS Number : 21187-98-4
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What is the Chemical Information of Gliclazide?

Chemical Name : Gliclazide
Category : API Standards
Purity : Not less than 95%
Molecular Weight : 323.41 mol/g
Molecular Formula : C₁₅H₂₁N₃O₃S
Application : A sulfonylurea hypoglycemic agent. Used as an antidiabetic.
Therapeutic : Anti-Diabetic

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Hazardous Compound : No

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References : "Duhault; J,; et al,: Arzneimittel-Forsch,; 22; 1686 (1972); Holmes; B,; et al,: Drugs; 27; 301 (1984);"
Canonical SMILES : CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
Isomeric SMILES : CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
InChI : InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
IUPAC Name : 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
Exact Mass : 323.13036271
Melting Point : 180-182
Solubility : 42.6 [ug/mL]
Hazard Class : Acute Tox. 4 (73.33%)
Description : Gliclazide is a N-sulfonylurea. It has a role as a hypoglycemic agent, a radical scavenger and an insulin secretagogue.
EC Number : 244-260-5
Toxicity Summary : LD50=3000 mg/kg (orally in mice). Gliclazide and its metabolites may accumulate in those with severe hepatic and/or renal dysfunction. Symptoms of hypoglycemia include: dizziness, lack of energy, drowsiness, headache and sweating.