Latanoprost

ISO 17034:
Catalog Number : CS-O-01807
CAS Number : 130209-82-4
Status : Available for immediate dispatch
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Product Information

Product Name : Latanoprost
Category : API Standards
Purity : Not less than 95%
Molecular Weight : 432.59 mol/g
Molecular Formula : C₂₆H₄₀O₅
Application : "Prostaglandin analog, used to treat glaucoma and other degenerative diseases of the eye."

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Status : Available for immediate dispatch
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Hazardous Compound : No

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Refund Policy : 30 days money back guarantee
References : "Rhee; D,J,; et al,: Clinic, Ophthalmol,; 2; 313 (2008); Hernandez; M,; et al,: Exp, Eye Res,; 86; 798 (2008); Nagata; T,; et al,: J, Pharmacol, Sci,; 106; 423 (2008); Ikeda; Y,; et al,: J, Ocular Pharmacol, Ther,; 24; 230 (2008);"
Canonical SMILES : CC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O
Isomeric SMILES : CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1CC[C@H](CCC2=CC=CC=C2)O)O)O
InChI : InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
InchIKey : GGXICVAJURFBLW-CEYXHVGTSA-N
IUPAC Name : propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
Exact Mass : 432.28757437
Solubility : 1.29e-02 g/L
Use Classification : Human Drugs -> EU pediatric investigation plans
Hazard Class : Acute Tox. 1 (44.83%)
Description : Latanoprost is a prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension. It has a role as an antiglaucoma drug, an antihypertensive agent, an EC 4.2.1.1 (carbonic anhydrase) inhibitor and a prodrug. It is a prostaglandins Falpha, a triol and an isopropyl ester. It derives from a latanoprost free acid.
EC Number : 634-172-9
Toxicity Summary : The oral LD50 in the rat is > 50 mg/kg. An overdose of latanoprost is not expected to result in dangerous patient outcomes, however, conjunctival or episcleral hyperemia may occur.An intravenous infusion of 3 μg/kg of latanoprost in healthy volunteers led to mean plasma concentrations of 200 times higher than a normally administered therapeutic dose and no adverse effects were noted. One study suggested that an overdose of latanoprost lead to cystoid macular edema after a large, unintended overdose. This resolved within 4 weeks after 4 weeks following treatment with nepafenac 0.3% eye drops in addition to oral acetazolamide. Contact the local poison control center for updated guidance on the management of a latanoprost overdose.