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Chemical Properties of 'Sitagliptin D4 hydrochloride' |
|
CAT No. : |
CS-O-02775 |
CAS Registry No. : | 1426173-93-4 (freebase) |
Category : | Isotope Labelled Compounds |
Molecular Weight: | 447.80 |
Molecular Formula : | C₁₆H₁₂D₄ClF₆N₅O |
Controlled Substance : | NO |
Documents: | View Sample COA View Sample MSDS |
OTHER INFORMATION of 'Sitagliptin D4 hydrochloride' |
|
Purity : | Not less than 90 % |
Therapeutic : | Antibiotics |
Isotopic Enrichment : | Not less than 95 % |
Applicationnotes : | "Labeled Sitagliptin, intended for use as an internal standard for the quantification of Sitagliptin by GC- or LC-mass spectrometry." |
Synonym : | NA |
References : | "Kim; D,; et al,: J, Med, Chem,; 48; 141 (2005); Ahren; B,; et al,: Eur, J, Pharmacol,; 521 164 (2005);" |
Smileys : | FC(F)(C1=NN=C2N1C([2H])([2H])C([2H])([2H])N(C(C[C@H](N)CC(C=C(F)C(F)=C3)=C3F)=O)C2)F.Cl |
Appearance : | White to off white to yellow solid |
Custom Duty : | Applicable |
Port of Loading : | Canada |
Expected Dispatch : | 13-Aug-2022 |
Taxes : | Not Applicable |
Refund Policy : | 30-days money back |
Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. It is taken by mouth. It is also available in the fixed-dose combination medication sitagliptin/metformin (Janumet, Janumet XR).
Common side effects include headaches, swelling of the legs, and upper respiratory tract infections. Serious side effects may include angioedema, low blood sugar, kidney problems, pancreatitis, and joint pain. Whether use in pregnancy or breastfeeding is safe is unclear. It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decreasing the production of glucagon by the pancreas.
Sitagliptin was developed by Merck & Co. and approved for medical use in the United States in 2006. In 2019, it was the 88th most commonly prescribed medication in the United States, with more than 8\u00a0million prescriptions.
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