Brompheniramine

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Catalog Number : CS-O-06170
CAS Number : 86-22-6
Status : Available for immediate dispatch
Category : API Standards
Purity : >98%
Molecular Weight : 319.24 mol/g
Molecular Formula : C16H19BrN2
Therapeutic : Antihistamine
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Application : "Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria."
Synonyms : 3-(4-bromophenyl)-N;N-dimethyl-3-pyridin-2-yl-propan-1-amine
Payment mode : Credit / Debit / Purchase Order
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Refund Policy : 30 days money back guarantee
Canonical SMILES : CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
Isomeric SMILES : CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
InChI : InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
InchIKey : ZDIGNSYAACHWNL-UHFFFAOYSA-N
Related CAS : 980-71-2 (maleate (1:1))
IUPAC Name : 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Exact Mass : 318.07316
Color : Oily liquid with slightly yellow color
Odor : Characteristic amine-like
Melting Point : < 25 °C
Solubility : Freely soluble (maleate salt)
Use Classification : Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Hazard Class : Acute Tox. 4 (100%)
Description : Brompheniramine is pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. It has a role as a H1-receptor antagonist and an anti-allergic agent. It is a member of pyridines and an organobromine compound.
Disposal Methods : SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
EC Number : 201-657-8
Vapor Pressure : 4.63X10-5 mm Hg at 25 °C (est)
Toxicity Summary : Oral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
Antidoteand Emergency Treatment : Emergency and supportive measures: Maintain an open airway and assist ventilation if necessary. Treat coma, seizures, hyperthermia, and atypical ventricular tachycardia if they occur. Monitor the patient for at least 6 to 8 hours after ingestion. Specific drugs and antidotes: There is no specific antidote for antihistamine overdose. As for anticholinergic poisoning, physostigmine has been used for treatment of severe delirium or tachycardia. However because antihistamine overdose carry a greater risk for seizures physostigmine is not recommended routinely. Sodium bicarbonate may be useful for myocardial depression ... . Decontamination: Administer activated charcoal orally if conditions are appropriate. Gastric lavage is not necessary after small to moderate ingestions if activated charcoal can be given promptly. Because of slowed gastrointestinal motility, gut decontamination procedures may be helpful even in late-presenting patients. Enhanced elimination: Hemodialysis, hemoperfusion, peritoneal dialysis, and repeat dose activated charcoal are not effective in removing antihistamines. /Antihistamines/
Human Toxicity Excerpts : /SIGNS AND SYMPTOMS/ In acute poisoning with H1 antagonists, their central excitatory effects constitute the greatest danger. The syndrome includes hallucinations, excitement, ataxia, incoordination, athetosis, and convulsions. Fixed, dilated pupils with a flushed face, together with sinus tachycardia, urinary retention, dry mouth, and fever, lend the syndrome a remarkable similarity to that of atropine poisoning. Terminally, there is deepening coma with cardiorespiratory collapse and death, usuallY within 2 to 18 hours. Treatment is along general symptomatic and supportive lines. /Histamine Antagonists: H1 Antagonists/

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