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Cinacalcet



Chemical Properties of 'Cinacalcet'

CAT No. :

CS-O-07622
CAS Registry No. : 226256-56-0
Category : API Standards
Molecular Weight: 357.41
Molecular Formula : C22H22F3N



OTHER INFORMATION of 'Cinacalcet'
Purity : >98%
Purity : >98%
IUPAC Name :N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
Synonym :364782-34-3;(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine.
Smileys :C[C@H](C1=CC=CC2=C1C=CC=C2)NCCCC3=CC(C(F)(F)F)=CC=C3
Related CAS : 364782-34-3 (Hydrochloride)
Solubility :Slightly soluble (in HCl salt form)
Use Classification :Human drugs -> Cinacalcet Accordpharma -> EMA Drug Category
Hazard Class :Acute Tox. 4 (100%)
EC Number :682-701-7
UNII :UAZ6V7728S
RXCUI :407990
MeSH Entry Terms :alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride
Other Synonyms :Cinacalcet
Removed Synonyms :Mimpara
Vapor Pressure : 1.5X10-7 mm Hg at 25 °C at 25 °C /Estimated/
Other Experimental Properties :White to off white crystalline solid. Soluble in methanol. Soluble in 95% ethanol. Slightly soluble in water. /Hydrochloride/
Disposal Methods :SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Toxicity Summary :Doses titrated up to 300 mg once daily have been safely administered to patients on dialysis. Overdosage of cinacalcet may lead to hypocalcemia.
Drug Induced Liver Injury :cinacalcet
Interactions :Potential pharmacokinetic interaction (increased plasma concentrations of drugs metabolized principally by cytochrome P450 (CYP) isoenzyme 2D6). In patients receiving cinacalcet 25 or 100 mg concurrently with amitriptyline hydrochloride 50 mg, exposure to amitriptyline and its active metabolite, norrtiptyline, was increased by 20%. Dosage adjustment maybe required if cinacalcet is administered concomitantly with ta drug that has a narrow therapeutic index and is metabolized principally by CYP2D6 (e.g., flecainide, vinblastine, thioridazine, most tricyclic antidepressants).
Antidoteand Emergency Treatment :Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/
Non Human Toxicity Excerpts :/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ In mice and rat studies with cinacalcet exposures of up to 2 times those resulting with a human oral dose of 180 mg per day based on AUC comparison, no increased incidence of tumors was observed .
Protein Binding :Approximately 93 to 97% bound to plasma proteins.
Exact Mass :357.17043419
InChI :InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1
InchIKey :VDHAWDNDOKGFTD-MRXNPFEDSA-N
Canonical SMILES :CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Isomeric SMILES :C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Product Description :Cinacalcet is a secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group. It has a role as a calcimimetic and a P450 inhibitor. It is a member of naphthalenes, a secondary amino compound and a member of (trifluoromethyl)benzenes.
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 2-3 Weeks
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 2-3 Weeks
Taxes : Not Applicable
Refund Policy : 30-days money back


More information about Cinacalcet


Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat tertiary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism.

The most common side effects include nausea (feeling sick) and vomiting.

Cinacalcet acts as a calcimimetic (i.e., it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.

Cinacalcet was approved in the United States in March 2004, and in the European Union in October 2004. It was the first allosteric G protein-coupled receptor modulator to enter the pharmaceutical market. In 2013, cinacalcet was the 76th top prescribed medicine in the United States.




This page contains information about Cinacalcet , Cinacalcet cas, Cinacalcet synthesis, Cinacalcet suppliers

What is Cinacalcet ?
Cinacalcet falls under API Standards of Cinacalcet.
What is the CAS Number of Cinacalcet?
The CAS Number of Cinacalcet is 226256-56-0
Who are the suppliers of Cinacalcet?
CLEARSYNTH is a worldwide supplier of Cinacalcet

List of Cinacalcet API Standards

Related compounds of Cinacalcet

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