Chemical Properties of 'Canagliflozin D4' |
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CAT No. : |
CS-O-10809 |
CAS Registry No. : | 1997338-61-0 |
Category : | Isotope Labelled Compounds |
Molecular Weight: | 448.54 |
Molecular Formula : | C₂₄H₂₁D₄FO₅S |
OTHER INFORMATION of 'Canagliflozin D4' |
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Purity : | Not less than 90% |
Therapeutic : | Anti-Diabetic |
Isotopic Enrichment : | Not Specified |
Purity : | Not less than 90% |
Therapeutic : | Anti-Diabetic |
Isotopic Enrichment : | Not Specified |
IUPAC Name : | (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-[4-methyl-3-[[5-(2,3,5,6-tetradeuterio-4-fluorophenyl)thiophen-2-yl]methyl]phenyl]oxane-3,4,5-triol |
Applicationnotes : | "Labeled Canagliflozin; Canagliflozin Stable Isotope;Labeled Canagliflozin, intended for use as an internal standard for the quantification of Canagliflozin by GC- or LC-mass spectrometry." |
Synonym : | Not available |
References : | "Chao, E, et al,: Drug Fut,, 36, 351 (2011); Sha, S, et al,: Diab, Obes, Metab,, 13, 669 (2011); Kipnes, M,S,: Clin, Invest,, 1, 145 (2011);" |
Smileys : | O[C@H]1[C@H](C2=CC(CC3=CC=C(C(C([2H])=C4[2H])=C(C([2H])=C4F)[2H])S3)=C(C)C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O |
Appearance : | Off white to white solid |
Other Synonyms : | Canagliflozin D4 |
Removed Synonyms : | CS-O-10809 |
Exact Mass : | 448.16578021 |
InChI : | InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1/i4D,5D,6D,7D |
InchIKey : | XTNGUQKDFGDXSJ-OQRSEGJPSA-N |
Canonical SMILES : | CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F |
Isomeric SMILES : | [2H]C1=C(C(=C(C(=C1C2=CC=C(S2)CC3=C(C=CC(=C3)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C)[2H])[2H])F)[2H] |
Custom Duty : | Applicable |
Port of Loading : | Canada |
Expected Dispatch : | 15-Aug-2022 |
Taxes : | Not Applicable |
Refund Policy : | 30-days money back |
Custom Duty : | Applicable |
Port of Loading : | Canada |
Expected Dispatch : | 15-Aug-2022 |
Taxes : | Not Applicable |
Refund Policy : | 30-days money back |
Canagliflozin, sold under the brand name Invokana among others, is a medication used to treat type 2 diabetes. It is a third-line medication to be tried after metformin, a first-line medication for type 2 diabetes. It is used together with exercise and diet. It is not recommended in type 1 diabetes. It is taken by mouth.
Common side effects include vaginal yeast infections, nausea, constipation, and urinary tract infections. Serious side effects may include low blood sugar, Fournier's gangrene, leg amputation, kidney problems, high blood potassium, and low blood pressure. Diabetic ketoacidosis may occur despite nearly normal blood sugar levels. Use in pregnancy and breastfeeding is not recommended. Canagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by increasing the amount of glucose lost in the urine.
Canagliflozin was approved for medical use in the United States, in the European Union, and in Australia in 2013. It is on the World Health Organization's List of Essential Medicines. In 2018, it was the 191st most commonly prescribed medication in the United States, with more than 3\u00a0million prescriptions.
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