ISO 17034:
Catalog Number : CS-O-11300
CAS Number : 114977-28-5
Status : Available for immediate dispatch
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What is the Chemical Information of Docetaxel?

Chemical Name : Docetaxel
Category : API Standards
Purity : Not less than 95%
Molecular Weight : 807.88 mol/g
Molecular Formula : C₄₃H₅₃NO₁₄
Application : "Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent."
Therapeutic : Anti-Cancer / Oncology

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References : "Ringel; I,; et al,: J, Natl, Cancer Inst,; 83; 288 (1991); Extra; J,-M,; et al,: Cancer Res,; 53; 1037 (1993)"