Betaxolol

ISO 17034:
Betaxolol

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Catalog Number : CS-O-11609
CAS Number : 63659-18-7
Status : Available for immediate dispatch
Category : API Standards
Purity : >98%
Molecular Weight : 307.43 mol/g
Molecular Formula : C₁₈H₂₉NO₃
Therapeutic : Anti-Cancer / Oncology
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Status : Available for immediate dispatch
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Hazardous Compound : No

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Application : Cardioselective ß1-adrenergic blocker. An antihypertensive; antiglaucoma.
Payment mode : Credit / Debit / Purchase Order
Taxes : All prices are inclusive taxes
Refund Policy : 30 days money back guarantee
References : "Cadigan, P,J,, et al,: Br, J, Clin, Pharmacol,, 9, 569 (1980), Pathe, M,, et al,: Therapie, 37, 75 (1982),"
Canonical SMILES : CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O
Isomeric SMILES : CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O
InChI : InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
InchIKey : NWIUTZDMDHAVTP-UHFFFAOYSA-N
Related CAS : 63659-19-8 (hydrochloride)
IUPAC Name : 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol
Exact Mass : 307.21474379
Melting Point : 70-72 °C
Use Classification : Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Hazard Class : Acute Tox. 4 (100%)
Description : Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure. It has a role as a beta-adrenergic antagonist, an antihypertensive agent and a sympatholytic agent.
EC Number : 613-310-1
Toxicity Summary : Oral LD50s are 350 to 400 mg betaxolol/kg in mice and 860 to 980 mg/kg in rats. Predicted symptoms of overdose include bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia.

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