OTHER INFORMATION
of 'Torsemide'
|
| Purity : |
Not less than 95% |
| Purity : |
Not less than 95% |
| IUPAC Name : | 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea |
| Chemical name of this compound, computed from its structure based on the International Union of Pure and Applied Chemistry (IUPAC) nomenclature standards. |
| Synonym : | Not available |
| References : | "Lesne; M,; et al,: In, J, Clin, Pharmacol, Ther, Toxicol,; 20; 382 (1982); Brater; D,C,; et al,: Clin, Pharmacol, Ther,; 42; 187 (1987);" |
| Appearance : | White to off white solid |
| Melting Point : | 163-164 °C |
| Solubility : | >52.3 [ug/mL] |
| Use Classification : | Veterinary drugs -> UpCard -> EMA Drug Category |
| This section contains use classification/category information for this compound from various sources. |
| Hazard Class : | Eye Irrit. 2 (88.57%) |
| The Hazard Classes and Categories are aligned with GHS (Globally Harmonized System of Classification and Labelling of Chemicals) hazard statement codes. |
| EC Number : | 637-197-3 |
| The European Community (EC) number is a seven-digit identifier assigned by the European Chemicals Agency (ECHA) to substances for regulatory purposes within the European Union. EC numbers are sometimes referred to as EINECS, ELINCS, or NLP numbers |
| UNII : | W31X2H97FB |
| UNique Ingredient Identifier (UNII) code for this chemical. It is a non-proprietary registry number assigned by the U.S. Food and Drug Administration (FDA). |
| NCI Thesaurus Code : | C29506 |
| Stable, unique code for biomedical concept |
| RXCUI : | 38413 |
| Stable, unique code for biomedical concept |
| MeSH Entry Terms : | 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea |
| Medical Subject Heading (MeSH) names or identifiers matching this PubChem Compound record. The matching between the MeSH and compound records is performed by name matching (i.e., identical common names) |
| Other Synonyms : | Torasemide |
| Removed Synonyms : | Presoril |
| Label Ingredient : |
TORSEMIDE |
| Active ingredient(s) of the drug product. |
| NDC Code : | 0004-0262-01, 0004-0262-49, 0004-0263-01, 0004-0263-49, 0004-0264-01, 0004-0264-49, 0004-0265-01, 0004-0265-49, 0004-0267-06, 0004-0268-06 ... total 99. |
| U.S. Food & Drug Administration (FDA)'s National Drug Code (NDC) for the drug product. |
| Metabolite Pathways : | Torsemide Action Pathway |
| Metabolic pathways related to this chemical. A metabolic pathway is a series of chemical reactions in a cell that build and breakdown molecules for cellular processes. |
| Toxicity Summary : | The oral LD50 of torasemide in the rat is 5 g/kg. When overdose occurs, there is a marked diuresis with the danger of loss of fluid and electrolytes which has been seen to lead to somnolence, confusion, hypotension, hyponatremia, hypokalemia, hypochloremic alkalosis, hemoconcentration dehydration and circulatory collapse. This effects can include some gastrointestinal disturbances. There is no increase in tumor incidence with torasemide and it is proven to not be mutagenic, not fetotoxic or teratogenic. |
| Summary of the toxicity of this compound, provided by the Hazardous Substances Data Bank (HSDB). |
| Drug Induced Liver Injury : | torasemide |
| This compound's potential to cause drug-induced liver injury. This information is from the FDA's Drug-Induced Liver Injury Rank (DILIrank) dataset |
| Protein Binding : | Torasemide is found to be highly bound to plasma proteins, representing over 99% of the administered dose. |
| In this section, "protein binding" refers to the degree to which medications attach to plasma proteins (i.e., proteins within the blood, such as human serum albumin, lipoprotein, glycoprotein and globulins) |
| Exact Mass : | 348.12561169 |
| The exact mass of an isotopic species is obtained by summing the masses of the individual isotopes of the molecule. |
| InChI : | InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) |
| The International Chemical Identifier (InChI) is a computed, non-proprietary identifier for a chemical structure. The InChI is an International Union of Pure and Applied Chemistry (IUPAC) standard. |
| InchIKey : | NGBFQHCMQULJNZ-UHFFFAOYSA-N |
| An InChIKey is a 27-character hash code derived from an InChI. The International Chemical Identifier (InChI) is a computed, non-proprietary identifier for a chemical structure. |
| Canonical SMILES : | CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C |
| The Simplified Molecular-Input Line-Entry System (SMILES) is a widely-used line notation for chemical structures. |
| Isomeric SMILES : | CC1=CC(=CC=C1)NC2=C(C=NC=C2)S(=O)(=O)NC(=O)NC(C)C |
| The Simplified Molecular-Input Line-Entry System (SMILES) is a widely-used line notation for chemical structures. |
| Product Description : | Torasemide is an N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure. It has a role as a loop diuretic and an antihypertensive agent. It is a N-sulfonylurea, an aminopyridine and a secondary amino compound. It derives from a 4-aminopyridine. |
| Custom Duty : |
Applicable |
| Port of Loading : |
Canada |
| Expected Dispatch : |
2-3 Weeks |
| Taxes : |
Not Applicable |
| Refund Policy : |
30-days money back |
| Custom Duty : |
Applicable |
| Port of Loading : |
Canada |
| Expected Dispatch : |
2-3 Weeks |
| Taxes : |
Not Applicable |
| Refund Policy : |
30-days money back |
