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Hydroxychloroquine



Chemical Properties of 'Hydroxychloroquine'

CAT No. :

CS-O-15317
CAS Registry No. : 118-42-3
Category : Fine Chemicals
Molecular Weight: 335.87
Molecular Formula : C₁₈H₂₆ClN₃O



OTHER INFORMATION of 'Hydroxychloroquine'
Purity : >98%
Purity : >98%
IUPAC Name :2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
Synonym :Not available
Smileys :CC(CCCN(CC)CCO)NC1=CC=NC2=CC(Cl)=CC=C12
Related CAS : 747-36-4 (sulfate (1:1) salt)
Melting Point :89-91
Solubility :2.61e-02 g/L
Use Classification :Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Hazard Class :Acute Tox. 4 (100%)
EC Number :204-249-8
MeSH Entry Terms :Hydroxychlorochin
Other Synonyms :hydroxychloroquine
Removed Synonyms :Oxychloroquine
Toxicity Summary :Patients experiencing an overdose may present with headache, drowsiness, visual disturbances, cardiovascular collapse, convulsions, hypokalemia, rhythm and conduction disorders including QT prolongation, torsades de pointes, ventricular tachycardia, and ventricular fibrillation. This may progress to sudden respiratory and cardiac arrest. Overdose should be treated with immediate gastric lavage and activated charcoal at a dose of at least 5 times the hydroxychloroquine dose within 30 minutes. Parenteral diazepam may be given to treat cardiotoxicity, transfusion may reduce serum concentrations of drug, patients should be monitored for at least 6 hours, fluids should be given, and ammonium chloride should be given to acidify urine and promote urinary excretion. Patients may also be given epinephrine.
Hepatotoxicity :Hydroxychloroquine has not been associated with significant serum enzyme elevations during therapy of rheumatologic diseases. Furthermore, clinically apparent liver injury from hydroxychloroquine is rare. A single case series (two cases) of acute liver failure attributed to hydroxychloroquine was published twenty years ago, but case reports of clinically apparent liver injury have not appeared subsequently. Thus, acute liver injury with jaundice due to hydroxychloroquine must be very rare, if it occurs at all. In clinical trials of hydroxychloroquine for COVID-19 prevention and treatment, there were no reports of hepatotoxicity and rates of serum enzyme elevations during hydroxychloroquine treatment were low and similar to those in patients receiving placebo or comparator agents.
Drug Induced Liver Injury :hydroxychloroquine
Protein Binding :The S enantiomer of hydroxychloroquine is 64% protein bound in plasma. It is 50% bound to serum albumin and 29% bound to alpha-1-acid glycoprotein. The R enantiomer is 37% protein bound in plasma. It is 29% bound to serum albumin and 41% bound to alpha-1-acid glycoprotein. In total, hydroxychloroquine is 50% protein bound in plasma.
Exact Mass :335.1764402
InChI :InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
InchIKey :XXSMGPRMXLTPCZ-UHFFFAOYSA-N
Canonical SMILES :CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
Isomeric SMILES :CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
Product Description :Hydroxychloroquine is an aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions. It has a role as an antimalarial, an antirheumatic drug, a dermatologic drug and an anticoronaviral agent. It is an aminoquinoline, an organochlorine compound, a primary alcohol, a secondary amino compound and a tertiary amino compound. It derives from a chloroquine. It is a conjugate base of a hydroxychloroquine(2+).
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 15-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 15-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back


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This page contains information about Hydroxychloroquine , Hydroxychloroquine cas, Hydroxychloroquine synthesis, Hydroxychloroquine suppliers

What is Hydroxychloroquine ?
Hydroxychloroquine falls under Fine Chemicals of Hydroxychloroquine.
What is the CAS Number of Hydroxychloroquine?
The CAS Number of Hydroxychloroquine is 118-42-3
Who are the suppliers of Hydroxychloroquine?
CLEARSYNTH is a worldwide supplier of Hydroxychloroquine

List of Hydroxychloroquine Fine Chemicals

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