Lacidipine

ISO 17034:
Catalog Number : CS-O-30627
CAS Number : 103890-78-4
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Product Information

Product Name : Lacidipine
Category : API Standards
Purity : >98%
Molecular Weight : 455.54 mol/g
Molecular Formula : C₂₆H₃₃NO₆

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References : "Safar; M,; et al,:clin, Pharmcol, Ther,; 46; 94 (1989); Kharat; V,R,; et al,: J, Pharm, Biomed, Anal,; 28; 789 (2002); cCormck; A,J,; et al,: Drugs; 63; 2327 (2003);"
Canonical SMILES : CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2C=CC(=O)OC(C)(C)C)C(=O)OCC)C)C
Isomeric SMILES : CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2/C=C/C(=O)OC(C)(C)C)C(=O)OCC)C)C
InChI : InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
InchIKey : GKQPCPXONLDCMU-CCEZHUSRSA-N
IUPAC Name : diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
Exact Mass : 455.23078777
Hazard Class : Acute Tox. 4 (97.83%)
Description : Lacidipine is a cinnamate ester and a tert-butyl ester.
EC Number : 638-759-0
Toxicity Summary : There have been no recorded cases of lacidipine tablets overdosage. Some of the symptoms of overdose include prolonged peripheral vasodilation associated with hypotension and tachycardia. Bradycardia or prolonged AV conduction could theoretically occur. As there is no known antidote for lacidipine, the use of standard general measures for monitoring cardiac function and appropriate supportive and therapeutic measures is recommended. Oral LD50 in mouse, rabbit and rat are 300mg/kg, 3200mg/kg and 980mg/kg, respectively [MSDS].