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ISO 17034:
Catalog Number : CS-O-30794
CAS Number : 274693-27-5
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What is the Chemical Information of Ticagrelor?

Chemical Name : Ticagrelor
Category : API Standards
Purity : Not less than 95%
Molecular Weight : 522.57 mol/g
Molecular Formula : C₂₃H₂₈F₂N₆O₄S
Application : "Ticagrelor is a P2Y12 Platelet Inhibitor. The mechanism of action of is as a Phenylalanine Hydroxylase Activator, and P2Y12 Receptor Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A5 Inhibitor, and P-Glycoprotein Inhibitor. The physio"
Therapeutic : Anti-Thrombotics

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Hazardous Compound : Yes

More Information

Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y12 receptor. The drug is produced by AstraZeneca.
Payment mode : Credit / Debit / Purchase Order
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References : "Matetzky; S,; et al,:ciculation; 109; 3171 (2004); Bassand; J,; et al,: Eur, Heart J,; 28; 1598 (2007); Jakubowski; J,; et al,:cardiovac, Drug Rev,; 25; 357 (2007);"
Canonical SMILES : CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
Isomeric SMILES : CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
InChI : InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
IUPAC Name : (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Exact Mass : 522.18608089
Color : Crystalline powder
Use Classification : Human drugs -> Brilique -> EMA Drug Category
Hazard Class : Skin Irrit. 2 (11.11%)
Description : Ticagrelor is a triazolopyrimidine that is an adenosine isostere; the cyclopentane ring is similar to ribose and the nitrogen-rich [1,2,3]triazolo[4,5-d]pyrimidine moiety resembles the nucleobase adenine. A platelet aggregation inhibitor which is used for prevention of thromboembolic events in patients with acute coronary syndrome. It has a role as a platelet aggregation inhibitor and a P2Y12 receptor antagonist. It is a member of triazolopyrimidines, an organofluorine compound, an aryl sulfide, a secondary amino compound and a hydroxyether.
Disposal Methods : SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
EC Number : 619-540-9
Vapor Pressure : 1.21X10-20 mm Hg at 25 °C (est)
Toxicity Summary : Patients experiencing an overdose may present with bleeding, nausea, vomiting, diarrhea, and ventricular pauses. Overdose can be managed through symptomatic and supportive treatment, including ECG monitoring. Dialysis is not expected to remove ticagrelor from the blood due to it being highly protein bound.
Antidoteand Emergency Treatment : Ticagrelor is a direct-acting reversibly binding P2Y12 antagonist and is widely used as an antiplatelet therapy for the prevention of cardiovascular events in acute coronary syndrome patients. However, antiplatelet therapy can be associated with an increased risk of bleeding. Here, we present data on the identification and the in vitro and in vivo pharmacology of an antigen-binding fragment (Fab) antidote for ticagrelor. The Fab has a 20 pM affinity for ticagrelor, which is 100 times stronger than ticagrelor's affinity for its target, P2Y12. Despite ticagrelor's structural similarities to adenosine, the Fab is highly specific and does not bind to adenosine, adenosine triphosphate, adenosine 5'-diphosphate, or structurally related drugs. The antidote concentration-dependently neutralized the free fraction of ticagrelor and reversed its antiplatelet activity both in vitro in human platelet-rich plasma and in vivo in mice. Lastly, the antidote proved effective in normalizing ticagrelor-dependent bleeding in a mouse model of acute surgery. This specific antidote for ticagrelor may prove valuable as an agent for patients who require emergency procedures.
Human Toxicity Excerpts : /SIGNS AND SYMPTOMS/ Bleeding is the expected pharmacologic effect of overdosing. If bleeding occurs, appropriate supportive measures should be taken. Other effects of overdose may include gastrointestinal effects (nausea, vomiting, diarrhea) or ventricular pauses. Monitor the ECG.

What are the API Standards of Ticagrelor ?

CS-O-10086 Ticagrelor Metabolite-M5 D7 1251765-07-7 (Unlabeled) Ticagrelor Stable Isotopes
CS-EO-00311 Ticagrelor Related Compound 49 866551-95-3 Ticagrelor Impurities
CS-O-10084 Ticagrelor Metabolite-M5 1251765-07-7 Ticagrelor Metabolites
CS-O-06349 Ticagrelor Impurity A NA Ticagrelor Impurities
CS-O-36528 Ticagrelor (1S,2S)-isomer 2435586-40-4 Ticagrelor Impurities
CS-P-08787 Ticagrelor Related Compound 39 NA Ticagrelor Impurities
CS-P-08928 Ticagrelor Related Compound 102 2165387-08-4 Ticagrelor Impurities
CS-O-34125 Ticagrelor Sulfoxide Diastereoisomer-I NA Ticagrelor Impurities
CS-O-36383 Ticagrelor D4 1265911-54-3 Ticagrelor Stable Isotopes
CS-O-14871 "2,3-Difluoro Ticagrelor" 1643378-48-6 Ticagrelor Metabolites
CS-O-06359 Ticagrelor Impurity K N/A Ticagrelor Impurities
CS-O-13897 Ticagrelor Impurity 4 NA Ticagrelor Impurities
CS-P-08154 Ticagrelor N-Glucuronide Ticagrelor Glucuronides
CS-O-06356 Ticagrelor Impurity H N/A Ticagrelor Impurities
CS-O-13898 Ticagrelor Impurity 5 NA Ticagrelor Impurities
CS-O-34532 TICAGRELOR IMPURITY Ticagrelor Impurities
CS-O-05933 Ticagrelor Metabolite-M8 220347-05-7 Ticagrelor Metabolites
CS-O-13896 Ticagrelor Impurity 3 NA Ticagrelor Impurities
CS-P-08929 Ticagrelor Related Compound 103 2165566-46-9 Ticagrelor Impurities
CS-O-42617 Ticagrelor Metabolite-M5 HCl 1251765-07-7 (Freebase) Ticagrelor Metabolites
CS-O-06351 Ticagrelor Impurity C 2096989-55-6 Ticagrelor Impurities
CS-P-08790 Ticagrelor Related Compound 53 NA Ticagrelor Impurities
CS-P-08792 Ticagrelor Impurity 17 NA Ticagrelor Impurities
CS-O-37159 N-Nitrosamine Ticagrelor 2476859-55-7 Ticagrelor Impurities
CS-O-06362 Ticagrelor Impurity N NA Ticagrelor Impurities
CS-P-08153 Ticagrelor Related Compound 97 (AR-C124910XX-O-Glucuronide) NA Ticagrelor Glucuronides
CS-EO-00692 Ticagrelor Related Compound 91 NA Ticagrelor Impurities
CS-T-88379 5-Desthiopropyl-5-hydroxy-ticagrelor 1644461-81-3 Ticagrelor Impurities
CS-O-36160 Desethoxyhydroxy Ticagrelor-d7 NA Ticagrelor Stable Isotopes
CS-O-06353 Ticagrelor Impurity E NA Ticagrelor Impurities
CS-O-06357 Ticagrelor Impurity I N/A Ticagrelor Impurities
CS-O-13895 Ticagrelor Impurity 2 NA Ticagrelor Impurities
CS-O-36527 Ticagrelor (1R,2R)-isomer 2056269-94-2 Ticagrelor Impurities
CS-T-94567 Deshydroxyethoxy-2,3-O-(dimethylmethylene) Ticagrelor-d7 274693-49-1 (Unlabelled) Ticagrelor Stable Isotopes
CS-P-08791 Ticagrelor Related Compound 58 NA Ticagrelor Impurities
CS-EO-00894 Ticagrelor Impurity 78 2476859-56-8 Ticagrelor Impurities
CS-P-08796 Ticagrelor Impurity 64 NA Ticagrelor Impurities
CS-P-02241 Ticagrelor Related Compound 90 HCl 1487958-68-8 (Freebase) Ticagrelor Impurities
CS-EO-00288 Ticagrelor Desfluoro analogue NA Ticagrelor Impurities
CS-EO-00893 Ticagrelor Impurity 62 2476859-55-7 Ticagrelor Impurities
CS-O-37911 Desethoxyhydroxy ticagrelor NA Ticagrelor Impurities
CS-P-08794 Ticagrelor Impurity 52 NA Ticagrelor Impurities
CS-O-06354 Ticagrelor Impurity F 1616703-93-5 Ticagrelor Impurities
CS-O-33098 Ticagrelor TCG Sulfonate Ticagrelor Impurities
CS-EO-00765 Ticagrelor Related Compound 72 NA Ticagrelor Impurities
CS-EO-01040 Ticagrelor IP impurity C 2417326-48-6 Ticagrelor Impurities
CS-EO-00070 Ticagrelor Related Compound 38 2165881-71-8 Ticagrelor Impurities
CS-O-03658 Ticagrelor metabolite-M8 D7 220347-05-7 (Unlabeled) Ticagrelor Stable Isotopes
CS-P-08789 Ticagrelor Related Compound 46 2205903-73-5 Ticagrelor Impurities
CS-EO-01010 Ticagrelor IP impurity D 2417798-14-0 Ticagrelor Impurities