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Sorafenib tosylate

ISO 17034:
Catalog Number : CS-O-31023
CAS Number : 475207-59-1
Status : Available for immediate dispatch
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Chemical Information

Chemical Name : Sorafenib tosylate
Category : API Standards
Purity : Not less than 95%
Synonyms : Not available
Molecular Weight : 637.03 mol/g
Molecular Formula : C₂₈H₂₄ClF₃N₄O₆S
Application : "Sorafenib tosylate;Sorafenib & its intermediates;Sorafinib mesylate;4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate;Sorafenib Tosylate(Bay 43-9006,Nexavar);"
Therapeutic : Anti-Cancer / Oncology

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Status: : Available for immediate dispatch
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Hazardous Compound : No

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Additional Information

Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma.

References : "Richly; H,; et al,: Int, J, Clin, Pharmacol, Ther,; 41; 620 (2003); Khire; U,R,; et al,: Bioorg, Med, Chem, Lett,; 14; 783 (2004); Wilhelm; S,M,; et al,: Cancer Res,; 64; 7099 (2004); Rini; B,I,; et al,: Expert Opin, Pharmacother,; 7; 453 (2006);"
Canonical SMILES : CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Isomeric SMILES : CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
InChI : InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)
InchIKey : IVDHYUQIDRJSTI-UHFFFAOYSA-N
IUPAC Name : 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid
Exact Mass : 636.1057179
Use Classification : Human drugs -> Orphan -> Nexavar -> EMA Drug Category
Hazard Class : Acute Tox. 4 (32.5%)
Description : Sorafenib tosylate is an organosulfonate salt. It contains a sorafenib.
EC Number : 641-758-8

Related compounds of Sorafenib tosylate

CAT NO. COMPOUND CAS NO. CATEGORY
CS-O-11744 Sorafenib 284461-73-0 API Standards