Lopinavir EP Impurity P

ISO 17034:
Catalog Number : CS-O-32551
CAS Number : 1217628-64-2
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What is the Chemical Information of Lopinavir EP Impurity P?

Chemical Name : Lopinavir EP Impurity P
Category : Impurities
Purity : >98
Synonyms : (S)-N-((2R,4S,5S)-5-(2-(2,6-Dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide; (2R,4S,5S)-Lopinavir
Molecular Weight : 628.8 mol/g
Molecular Formula : C37H48N4O5
Therapeutic : Antiretroviral / Anti-HIV

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Canonical SMILES : CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O
Isomeric SMILES : CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O
InChI : InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)
InchIKey : KJHKTHWMRKYKJE-UHFFFAOYSA-N
IUPAC Name : N-[5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Exact Mass : 628.36247064
Color : Colorless solid from ethyl acetone
Melting Point : 124-127 °C
Solubility : In water, 7.7X10-3 mg/L at 25 °C (est)
Hazard Class : Skin Irrit. 2 (90.16%)
Disposal Methods : SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
EC Number : 844-598-9
Vapor Pressure : 3.4X10-24 mm Hg at 25 °C (est)
Antidoteand Emergency Treatment : /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
Human Toxicity Excerpts : /CASE REPORTS/ A French Caucasian man aged 39 with HIV infection was treated with abacavir/lamivudine and ritonavir/lopinavir. The patient (normal renal and liver functions) was diagnosed with a Burkitt lymphoma for which he was treated with cyclophosphamide day 1 to 5; doxorubicin day 1; methotrexate day 10; and vincristine day 1 and 8. At day 12, he suffered from abdominal pain associated with constipation. Paralytic ileus was diagnosed by study imaging. Ileus lasted 10 days necessitating parenteral feeding. Later on, a further cycle of chemotherapy with etoposide replacing vincristine was given and was well tolerated. /The researchers/ speculate that an interaction between ritonavir/lopinavir and vincristine was responsible for this severe toxicity. Vincristine is transported by P-gp and is metabolized via CYP3A5. Ritonavir is a potent CYP3A5 isoenzyme and P-gp inhibitor. Lopinavir is also a P-gp inhibitor. Ritonavir and lopinavir might have delayed vincristine elimination. Clinicians should be aware of this possible interaction.

What are the Impurities of Lopinavir ?

CAT NO. COMPOUND CAS NO. Category
CS-T-62793 "(2,6-Xylyloxy)acetyl Lopinavir" 943250-65-5 Lopinavir Impurities
CS-O-33258 Abacavir Lopinavir Methylene Conjugation NA Lopinavir Impurities
CS-EO-00402 Lopinavir 4R-Epimer NA Lopinavir Impurities
CS-P-05171 Lopinavir Aminoalcohol Impurity Lopinavir Impurities
CS-T-47854 Lopinavir EP Impurity A 192726-05-9 Lopinavir Impurities
CS-O-32540 Lopinavir EP Impurity B NA Lopinavir Impurities
CS-O-32541 Lopinavir EP Impurity C NA Lopinavir Impurities
CS-O-32542 Lopinavir EP Impurity D NA Lopinavir Impurities
CS-O-32543 Lopinavir EP Impurity E NA Lopinavir Impurities
CS-P-08106 Lopinavir EP Impurity F NA Lopinavir Impurities
CS-P-08107 Lopinavir EP Impurity G NA Lopinavir Impurities
CS-O-32539 Lopinavir EP Impurity H NA Lopinavir Impurities
CS-O-32544 Lopinavir EP Impurity I NA Lopinavir Impurities
CS-O-32545 Lopinavir EP Impurity J NA Lopinavir Impurities
CS-O-32546 Lopinavir EP Impurity k 1623021-24-8 Lopinavir Impurities
CS-O-32547 Lopinavir EP Impurity L NA Lopinavir Impurities
CS-O-32548 Lopinavir EP Impurity M NA Lopinavir Impurities
CS-O-32549 Lopinavir EP Impurity N 1798014-18-2 Lopinavir Impurities
CS-O-32550 Lopinavir EP Impurity O NA Lopinavir Impurities
CS-O-32552 Lopinavir EP Impurity Q 667904-94-1 Lopinavir Impurities
CS-O-30498 Lopinavir EP Impurity T 1797024-56-6 Lopinavir Impurities
CS-EO-00487 Lopinavir Impurity 1 NA Lopinavir Impurities
CS-EO-01956 Lopinavir Impurity B 943238-69-5 Lopinavir Impurities
CS-T-53641 Lopinavir Impurity R 943250-66-6 Lopinavir Impurities
CS-O-06367 Lopinavir Impurity S Not available Lopinavir Impurities
CS-P-05177 Lopinavir N-Formylphenoxyacetamide Impurity NA Lopinavir Impurities