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Tacrolimus Impurity III

(E)-17-allyl-1,14-dihydroxy-12-[(E)-2-(3, 4dihydroxycyclohexyl)-1-methylvinyl]-23, 25-dimethoxy-13, 19, 21, 27-tetramethyl-11, 28-dioxa-4azatricyclo[22.3.1.04.9]octacos-18-ene-2, 3, 10, 16-tetrone , 127984-76-3 , Tacrolimus Impurities | Clearsynth is a manufacturer and supplier of high purity Tacrolimus Impurity III


ISO 17034:
Catalog Number : CS-P-08639
CAS Number : 127984-76-3
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What is the Chemical Information of Tacrolimus Impurity III?

Chemical Name : Tacrolimus Impurity III
Category : Impurities
Synonyms : (E)-17-allyl-1,14-dihydroxy-12-[(E)-2-(3, 4dihydroxycyclohexyl)-1-methylvinyl]-23, 25-dimethoxy-13, 19, 21, 27-tetramethyl-11, 28-dioxa-4azatricyclo[22.3.1.04.9]octacos-18-ene-2, 3, 10, 16-tetrone
Molecular Weight : 790 mol/g
Molecular Formula : C43H67NO12

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Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. For example, it is prescribed for severe refractory uveitis after a bone marrow transplant, exacerbations of minimal change disease, Kimura's disease, and vitiligo. It can be used to treat dry eye syndrome in cats and dogs.

Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body's learned (or adaptive) immune response.
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Canonical SMILES : CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)O)O)C)O)C)OC)OC
Isomeric SMILES : CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)O)O)C)O)C)OC)OC
InChI : InChI=1S/C43H67NO12/c1-9-12-30-18-24(2)17-25(3)19-36(53-7)39-37(54-8)21-27(5)43(52,56-39)40(49)41(50)44-16-11-10-13-31(44)42(51)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(48)22-29/h9,18,20,25,27-33,35-39,45-46,48,52H,1,10-17,19,21-23H2,2-8H3
InchIKey : VHOPGJHKSPGXIZ-UHFFFAOYSA-N
IUPAC Name : 12-[1-(3,4-dihydroxycyclohexyl)prop-1-en-2-yl]-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Exact Mass : 789.46632657

What are the Impurities of Tacrolimus ?

CAT NO. COMPOUND CAS NO. CATEGORY
CS-P-08338 Tacrolimus EP Impurity H 143210-33-7 Tacrolimus Impurities
CS-O-39562 13-O-Desmethyl tacrolimus 139958-51-3 Tacrolimus Impurities
CS-ER-02047 Tacrolimus System Suitability Mixture(Secondary Standards traceble to USP) NA Tacrolimus Secondary Standards
CS-ED-00227 Oxacyclohexane Open Ring Tacrolimus 144432-23-5 Tacrolimus Impurities
CS-O-33256 Tacrolimus 21-carboxylic acid NA Tacrolimus Impurities
CS-O-30787 Tacrolimus 104987-11-3 Tacrolimus API Standards
CS-EO-01091 Tacrolimus EP Impurity F NA Tacrolimus Impurities
CS-O-33831 10-demetyl Tacrolimus NA Tacrolimus Impurities
CS-O-35447 Tacrolimus Related Compound A 135635-46-0 Tacrolimus Impurities
CS-EO-00735 Tacrolimus Impurity I 135821-69-1 Tacrolimus Impurities
CS-O-14037 Tacrolimus 13 DMT 132172-14-6 Tacrolimus Metabolites
CS-T-54717 Tacrolimus Impurity 2 131944-48-4 Tacrolimus Impurities
CS-P-08339 Tacrolimus Impurity 18 129039-81-2 Tacrolimus Impurities
CS-T-61570 Tacrolimus Methyl Acryl Aldehyde 109466-74-2 Tacrolimus Impurities
CS-T-53956 8-Epitacrolimus 129212-35-7 Tacrolimus Impurities
CS-T-59735 Tacrolimus impurity-1 123719-19-7 Tacrolimus Impurities
CS-O-03122 Tacrolimus 13CD2 1356841-89-8 Tacrolimus Stable Isotopes
CS-EB-02308 Tacrolimus (1642802) 104987-11-3 Tacrolimus USP Standards
CS-P-08961 Tacrolimus Impurity 23 NA Tacrolimus Impurities
CS-O-42141 12-Hydroxytacrolimus M-IV NA Tacrolimus Impurities
CS-O-08221 Tacrolimus 8-Propyl Analog 104987-30-6 Tacrolimus Impurities
CS-ER-02814 Tacrolimus(Secondary Standards traceble to USP) 104987-11-3 Tacrolimus Secondary Standards
CS-EG-01239 Tacrolimus for system suitability (Y0001933) NA Tacrolimus EP Standards
CS-EB-02852 Tacrolimus 8-Propyl Analog (1642835) 104987-30-6 Tacrolimus USP Standards
CS-O-34798 Tacrolimus Regioisomer NA Tacrolimus Impurities
CS-O-40120 Tacrolimus impurity 135821-70-4 Tacrolimus Impurities
CS-P-02134 Tacrolimus Impurity 6 1700657-83-5 Tacrolimus Impurities
CS-EO-00669 Tacrolimus Dehydro Impurity 129212-37-9 Tacrolimus Impurities
CS-O-38229 Tacrolimus Impurity 39 NA Tacrolimus Impurities
CS-O-13614 Tacrolimus-13CD4 104987-11-3 (Unlabeled) Tacrolimus Stable Isotopes
CS-EG-02488 Tacrolimus monohydrate (Y0001926) 109581-93-3 Tacrolimus EP Standards
CS-O-14039 Tacrolimus 15 DMT 151039-41-7 Tacrolimus Metabolites
CS-ER-02046 Tacrolimus 8-epimer(Secondary Standards traceble to USP) 129212-35-7 Tacrolimus Secondary Standards
CS-O-08223 Tacrolimus Monohydrate 109581-93-3 Tacrolimus API Standards
CS-P-00144 Tacrolimus Diene 104987-16-8 Tacrolimus Impurities
CS-EO-00736 Tacrolimus Impurity X 127285-26-1 Tacrolimus Impurities
CS-P-09045 Tacrolimus C4-epimer Diene NA Tacrolimus Impurities
CS-P-08636 Tacrolimus alpha-Hydroxy Acid (TAC-H1) NA Tacrolimus Impurities
CS-EO-01090 Tacrolimus EP Impurity B NA Tacrolimus Impurities
CS-EO-01009 Tacrolimus Impurity VII NA Tacrolimus Impurities
CS-O-08222 Tacrolimus Lactone Isomer 134590-88-8 Tacrolimus Impurities
CS-O-14038 Tacrolimus 31 DMT 135635-47-1 Tacrolimus Metabolites
CS-P-08282 Tacrolimus Ring-opening Impurity 1393890-33-9 Tacrolimus Impurities
CS-EB-02045 Tacrolimus Related Compound A (R053N0) 135635-46-0 Tacrolimus USP Standards
CS-P-08962 Tacrolimus Impurity 21 NA Tacrolimus Impurities