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5 GM | x |
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Chemical Properties of 'Acetamide' |
|
CAT No. : |
CS-T-00117 |
CAS Registry No. : | 60-35-5 |
Category : | Fine Chemicals |
Molecular Weight: | 59.07 |
Molecular Formula : | C₂H₅NO |
OTHER INFORMATION of 'Acetamide' |
|
Therapeutic : | Antiretroviral / Anti-HIV |
Therapeutic : | Antiretroviral / Anti-HIV |
IUPAC Name : | acetamide |
Synonym : | Daclatasvir Impurity-S |
Related CAS : | 74330-92-0 |
Color / Form : | Deliquescent hexagonal crystals |
ODOR : | Odorless when pure, but frequently has a mousy odor |
Melting Point : | 180.1 °F (NTP, 1992) |
Boiling Point : | 430 °F at 760 mm Hg (NTP, 1992) |
Solubility : | Very soluble (greater than or equal to 100 mg/mL at 72° F) (NTP, 1992) |
Density : | 1.159 at 68 °F (NTP, 1992) |
Chemical Classes : | Nitrogen Compounds -> Other Nitrogen Compounds |
Use Classification : | Hazardous Air Pollutants (HAPs) |
Hazard Class : | Carc. 2 |
EC Number : | 200-473-5 |
UNII : | 8XOE1JSO29 |
MeSH Entry Terms : | acetamide |
Other Synonyms : | acetamide |
Removed Synonyms : | Methylformamide |
Vapor Pressure : | 1 mm Hg at 149 °F (NTP, 1992) |
Other Experimental Properties : | Acetamide may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak base (weaker than water). |
Disposal Methods : | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. |
Toxicity Summary : | IDENTIFICATION AND USE: Acetamide is a solid. It is used as a solvent and stabilizer, accelerator in the estimation of bilirubin, antidote against monofluoroacetamide poisoning, and humectant for paper. HUMAN EXPOSURE AND TOXICITY: There are no data available. ANIMAL STUDIES: When acetamide was administered at a concentration of 5% in the diet to 99 male rats, with 2 rats returned to a control diet each week, liver tumors were found after treatment for 14-40 weeks in 22/81 rats. Acetamide-treated rats developed neoplastic nodules and hepatocellular carcinomas. The incidence, speed of onset, and frequency of metastases were greater in males than in females. Acetamide had the least toxic effects in regards to teratogenicity and embryotoxicity, compared to its derivatives. Acetamide produced morphological transformation in Syrian hamster embryo cells without metabolic activation. ECOTOXICITY STUDIES: Acetamide exhibited a selective damaging action on Entosiphon sulcatum. |
Interactions : | Two groups of 40 male wistar rats were fed diets containing 2.5% acetamide or 2.5% acetamide + 5.6 l-arginine, & 2 groups of 15 males were fed diet containing 5.6% arginine glutamate or a control diet for 1 yr. In 2/8 rats fed acetamide ... hepatomas ... were observed; 7/16 rats fed acetamide for 1 yr and maintained on control diet for further 3 MO developed liver tumors. In contrast, 1/11 rats that received acetamide + arginine glutamate for 1 yr and control diet for 3 MO had hyperplastic liver nodules. No liver tumors occurred in control group nor in rats fed 5.6% arginine glutamate alone. |
Antidoteand Emergency Treatment : | If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. When this chemical has been swallowed, get medical attention. ... If this chemical has been inhaled, remove from exposure and transfer promptly to a medical facility. |
Non Human Toxicity Excerpts : | /LABORATORY ANIMALS: Acute Exposure/ Max tolerated single dose for male rats and ... mice are 7.5 and 8 g/kg body wt, and corresponding LD50 values are 10.3 and 10.1 g/kg body wt (observed after 24 hr). |
Exact Mass : | 59.037113783 |
InChI : | InChI=1S/C2H5NO/c1-2(3)4/h1H3,(H2,3,4) |
InchIKey : | DLFVBJFMPXGRIB-UHFFFAOYSA-N |
Canonical SMILES : | CC(=O)N |
Isomeric SMILES : | CC(=O)N |
Hazard Summary : | Acetamide is used primarily as a solvent and a plasticizer. Workers may be exposed in the plastics and chemical industries. It causes mild skin irritation from acute (short-term) exposure. No information is available on the chronic (long-term), reproductive/developmental, or carcinogenic effects of acetamide in humans. EPA has not classified acetamide for carcinogenicity. |
Product Description : | Acetamide is a member of the class of acetamides that results from the formal condensation of acetic acid with ammonia. It is a monocarboxylic acid amide, a N-acylammonia and a member of acetamides. It is a tautomer of an acetimidic acid. |
Custom Duty : | Applicable |
Port of Loading : | Canada |
Expected Dispatch : | 15-Aug-2022 |
Taxes : | Not Applicable |
Refund Policy : | 30-days money back |
Custom Duty : | Applicable |
Port of Loading : | Canada |
Expected Dispatch : | 15-Aug-2022 |
Taxes : | Not Applicable |
Refund Policy : | 30-days money back |
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