Lidocaine impurity A

ISO 17034:
Catalog Number : CS-T-19784
CAS Number : 87-62-7
Status : Available for immediate dispatch
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Product Information

Product Name : Lidocaine impurity A
Category : Impurities
Purity : Not less than 90%
Synonyms : Xylazine EP impurity A
Molecular Weight : 121.18 mol/g
Molecular Formula : C₈H₁₁N
Application : Impurity in commercial preparations of Xylazine

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Hazardous Compound : No

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References : "Monge, A,, et al,: J, Med, Chem,, 38, 4488 (1995), El-Hawash, S,, et al,: Pharmazie, 54, 808 (1999), Rangisetty, J,, et al,: J, Pharm, Pharmacol,, 53, 1409 (2001),"
Canonical SMILES : CC1=C(C(=CC=C1)C)N
Isomeric SMILES : CC1=C(C(=CC=C1)C)N
InChI : InChI=1S/C8H11N/c1-6-4-3-5-7(2)8(6)9/h3-5H,9H2,1-2H3
Related CAS : 88374-65-6
IUPAC Name : 2,6-dimethylaniline
Exact Mass : 121.089149355
Color : Yellow liquid
Odor : Characteristic odor
Melting Point : 47.1 °F (NTP, 1992)
Boiling Point : 417 °F at 739 mm Hg (NTP, 1992)
Solubility : less than 1 mg/mL at 75° F (NTP, 1992)
Density : 0.984 (USCG, 1999)
Use Classification : Health Hazards -> Carcinogens
Hazard Class : Carc. 2
Description : 2,6-dimethylaniline is a primary arylamine that is aniline in which the hydrogens at the 2- and 6-positions are replaced by methyl groups. It is used in the production of some anasthetics and other chemicals. It is a drug metabolite of lidocaine (local anasthetic). It has a role as a carcinogenic agent and a drug metabolite. It is a primary arylamine and a dimethylaniline.
Disposal Methods : SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
EC Number : 201-758-7
Vapor Pressure : 1 mm Hg at 111.2 °F ; 5 mm Hg at 162.7° F; 100 mm Hg at 295° F (NTP, 1992)
Toxicity Summary : IDENTIFICATION AND USE: 2,6-Xylidine (2,6-DBA) is a yellow liquid. 2,6-DBA is an intermediate in manufacturing pesticides, dyes, antioxidants, pharmaceuticals, resins, fragrances, and other products. HUMAN EXPOSURE AND TOXICITY: Based on a Shanghai Bladder Cancer Study, which enrolled 581 incident bladder cancer cases and 604 population controls, hemoglobin adducts of 2,6-DBA were significantly and independently associated with increased bladder cancer risk among lifelong nonsmokers in Shanghai, China. The findings of that study in China, combined with with previous data in Los Angeles, California, strongly implicate arylamines as potential causal agents of human bladder cancer. ANIMAL STUDIES: 2,6-DBA was not a skin sensitizer at concentrations of 0, 5, 10 or 25% w/v in a mouse local lymphnode assay. Three rabbits were exposed to 0.1 mL 2,6-DBA; eyes were not washed out. The animals were observed for 8 days. Slight corneal opacity, iritis and chemosis were completely reversible within 8 days. Moderate conjunctivae redness was not fully reversible in 2/3 animals within 8 days. However, a clear trend over time for decreasing effect strength was observable, and in 1/3 animals the redness was completely reversible. Rats were exposed for 7 hours to a vapor saturated atmosphere (0.75 mg/L). 0/12 animals died after the 7 hour exposure. Salivation, apathy, closed eyes and slight secretion of the nose were reversible within one day. In male and female rats given 400-700 mg/kg by gavage daily for four weeks, however, decreased weight gain, lowered hemoglobin values and liver enlargement were observed, with increases in the levels of microsomal glucuronyltransferase in males and females and of aniline hydroxylase in females. Chronic dosing of male and female beagle dogs with oral doses of 50 mg/kg body weight 2,6-DBA for four weeks resulted in decreased body weight, hyperbilirubinemia, hypoproteinemia and, in contrast to rats, marked fatty degenerative changes in the liver. 2,6-DBA produced only weak positive genotoxicity results with Salmonella typhimurium strains TA97, TA98, TA100, TA1535, and TA1537. The oral administration of up to 350 mg/kg of 2,6-DBA did not result in the induction of micronuclei in bone marrow of male mice either at 24, 48 or 72 hours after dosing. In Chinese hamster ovary (CHO) cells, 2,6-DBA produced chromosomal aberrations and sister chromatid exchanges. In 2-year feed studies, 2,6-DBA was clearly carcinogenic for male and female rats, causing significant increases in the incidences of adenomas and carcinomas of the nasal cavity. A rhabdomyosarcoma, a rare tumor of the nasal cavity, was observed in dosed rats of each sex. In addition, the increased incidences of subcutaneous fibromas and fibrosarcomas in male and female rats and the increased incidence of neoplastic nodules of the liver in female rats may have been related to the administration of 2,6-DBA.
Antidoteand Emergency Treatment : Immediate First Aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aromatic hydrocarbons and related compounds/
Human Toxicity Excerpts : /SIGNS AND SYMPTOMS/ Exposure at high levels could cause lowering of consciousness. Exposure at high levels could cause formation of methemoglobin. The effects may be delayed. Medical observation is indicated. ... The substance may have effects on the blood. This may result in anemia. The substance may have effects on the liver.