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Metolazone



Chemical Properties of 'Metolazone'

CAT No. :

CS-T-35562
CAS Registry No. : 17560-51-9
Category : API Standards
Molecular Weight: 365.83
Molecular Formula : C₁₆H₁₆ClN₃O₃S



OTHER INFORMATION of 'Metolazone'
Purity : Not less than 95%
Isotopic Enrichment : Not Specified
Purity : Not less than 95%
Isotopic Enrichment : Not Specified
IUPAC Name :7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
Applicationnotes :A diruetic. An antihypertensive.
Synonym :Not available
References :"Curry, C,L,, et al,: Clin, Ther,, 9, 47 (1986), Kiyingi, A,, et al,: Lancet, 335, 29 (1990)"
Smileys :CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
Appearance :Off white to white solid
Color / Form :CRYSTALS FROM ETHANOL
ODOR :ODORLESS
Use Classification :Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Hazard Class :Skin Irrit. 2 (100%)
EC Number :241-539-3
UNII :NM7V2Y3G0U
MeSH Entry Terms :Diulo
Other Synonyms :metolazone
Removed Synonyms :Mykrox (TN)
Other Experimental Properties :ALSO REPORTED AS MP 246-250 °C (US PATENT 3,557,111)
Label Ingredient : METOLAZONE
NDC Code :0185-0055-01, 0185-0055-10, 0185-5050-01, 0185-5050-10, 0185-5600-01, 0185-5600-10, 0378-6172-01, 0378-6173-01, 0378-6174-01, 0527-2215-37 ... total 83.
Metabolite Pathways :Metolazone Action Pathway
Toxicity Summary :Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.
Drug Induced Liver Injury :metolazone
Interactions :...METOLAZONE...CHEMICALLY & PHARMACOLOGICALLY RELATED TO THIAZIDE DIURETICS & ELEVATE SERUM URATE LEVELS. ...MAY...INTERACT WITH PROBENECID.
Human Toxicity Excerpts :ADVERSE EFFECTS... ANOREXIA, GASTRIC IRRITATION, NAUSEA, VOMITING, CRAMPING, DIARRHEA, JAUNDICE, PANCREATITIS, SIALADENITIS, DIZZINESS, VERTIGO, PARESTHESIAS, HEADACHE, XANTHOPSIA, LEUKOPENIA, AGRANULOCYTOSIS, THROMBOCYTOPENIA, APLASTIC ANEMIA, ORTHOSTATIC HYPOTENSION. /THIAZIDES/
Protein Binding :50-70% bound to erythrocytes, up to 33% bound to plasma proteins, 2-5% of the drug in circulation is unbound
Exact Mass :365.0600902
InChI :InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
InchIKey :AQCHWTWZEMGIFD-UHFFFAOYSA-N
Canonical SMILES :CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
Isomeric SMILES :CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
Product Description :Metolazone is a quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics. It has a role as a diuretic, an antihypertensive agent and an ion transport inhibitor. It is a member of quinazolines, an organochlorine compound and a sulfonamide.
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 15-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 15-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back


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