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N-Nitrosopiperidine



Chemical Properties of 'N-Nitrosopiperidine'

CAT No. :

CS-T-37286
CAS Registry No. : 100-75-4
Category : Impurity Standards
Molecular Weight: 114.15
Molecular Formula : C₅H₁₀N₂O



OTHER INFORMATION of 'N-Nitrosopiperidine'
Purity : Not less than 90%
Purity : Not less than 90%
IUPAC Name :1-nitrosopiperidine
Synonym :Not available
Appearance :Clear to pale yellow liquid
Color / Form :Yellow oil
Melting Point :Vapor pressure
Boiling Point :423 °F at 721 mm Hg (NTP, 1992)
Solubility :10 to 50 mg/mL at 72° F (NTP, 1992)
Density :1.0631 at 65.3 °F (NTP, 1992)
Chemical Classes :Nitrogen Compounds -> Nitrosamines
Use Classification :Fire Hazards -> Carcinogens, Flammable - 2nd degree, Reactive - 1st degree
Hazard Class :Acute Tox. 3 (100%)
EC Number :202-886-6
UNII :6N066XUL4L
NCI Thesaurus Code :C44423
MeSH Entry Terms :N-nitrosopentamethyleneimine
Other Synonyms :N-NITROSOPIPERIDINE
Removed Synonyms :nitrosopiperidine
Vapor Pressure : 0.09 [mmHg]
Other Experimental Properties :Relatively resistant to hydrolysis but can be split by hydrogen bromide in acetic acid; strong oxidants (peracids) oxidize it to corresponding nitramine; can be reduced to corresponding hydrazine and/or amine
Disposal Methods :SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
Interactions :Mestranol was evaluated for mutagenicity in Salmonella histidine reversion assay. The pure form was not mutagenic in tester strains TA1535, TA100, TA98, TA1538, & TA1537. Mestranol & norethynodrel were capable of enhancing the mutation yield induced by an ineffective dosage of N-nitrosopiperidine.
Antidoteand Emergency Treatment :Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Nitrates, nitrites, and related compounds/
Human Toxicity Excerpts :/BIOMONITORING/ /The investigators/ assessed the exposure of total N-nitroso compounds (TNOCs) in the inhabitants of high- and low-risk areas for esophageal cancer in southern China. Samples of 24 hr diet and 12 hr overnight urine were collected from 120 male adults in each of the 2 areas, a high-risk area (Nan'ao County) and a low-risk area (Lufeng County) for esophageal cancer. Annual standardized mortality rates of esophageal cancer in Nan'ao and Lufeng are 110/10(6) and 10/10(6) respectively. The 240 healthy male subjects (35-64 years old) were selected by a 3-stage random cluster sample procedure. Levels of TNOCs, NAAs and volatile nitrosamines in the samples were measured. The TNOC detection rate (95%) in the diet, the TNOC daily intake (4.25 +/- 0.84 umol), TNOC excretion levels (0.04 +/- 0.01 nmol/12 hr) and daily intake of volatile nitrosamines (5.84 +/- 0.71 umol) in the high-risk area were significantly greater than values in the low-risk area (A +/- B = mean +/- SE). The TNOC detection rate in the diet, the TNOC daily intake, TNOC excretion levels and daily intake of volatile nitrosamines in the low-risk area were 70%, 0.25 +/- 0.06 umol, 0.02 +/- 0.01 nmol/12 hr and 3.18 +/- 0.31 umol, respectively. NAA excretion levels showed no difference between the 2 areas (16.3 +/- 7.18 umol/12 hr for Nan'ao and 31.2 +/- 26.4 umol/12 hr for Lufeng). Thus, TNOCs are implicated in the etiology of esophageal cancer in southern China. /N-nitroso compounds/
Non Human Toxicity Excerpts :/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ A group of 33 male ICR mice were fed a diet containing N-nitrosopiperidine at a concentration of 50 mg/kg of diet for 12 months. Of 24 surviving mice, 18 had squamous-cell carcinomas of the forestomach, two, papillomas of the esophagus, 11, liver tumors (two hepatocellular carcinomas, three hemangioendotheliomas, six liver adenomas) and 10, lung adenomas. Of the 30 control animals, two had lung adenomas and one, a lymphocytic leukemia.
Exact Mass :114.079312947
InChI :InChI=1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2
InchIKey :UWSDONTXWQOZFN-UHFFFAOYSA-N
Canonical SMILES :C1CCN(CC1)N=O
Isomeric SMILES :C1CCN(CC1)N=O
Hazard Summary :Danger of cutaneous absorption; MAC-2 (considered to be carcinogenic for man because sufficient data from long-term animal studies or limited evidence from animal studies substantiated by evidence from epidemiological studies indicate that it can make a significant contribution to cancer risk); [MAK] May cause irritation; Causes liver injury in high-dose animal studies; [MSDSonline]
Product Description :N-nitrosopiperidine is a nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. It has a role as a carcinogenic agent, an apoptosis inducer, a mutagen and an environmental contaminant. It is a nitrosamine and a piperidine.
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 15-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 15-Aug-2022
Taxes : Not Applicable
Refund Policy : 30-days money back


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