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1-Nitrosopyrrolidine



Chemical Properties of '1-Nitrosopyrrolidine'

CAT No. :

CS-T-37295
CAS Registry No. : 930-55-2
Category : Impurity Standards
Molecular Weight: 100.12
Molecular Formula : C₄H₈N₂O



OTHER INFORMATION of '1-Nitrosopyrrolidine'
IUPAC Name :1-nitrosopyrrolidine
Synonym :N-Nitrosopyrrolidine
Smileys :C1CCN(C1)N=O
Appearance :Pale yellow to yellow oil
Color / Form :Yellow liquid
Melting Point :Vapor pressure
Boiling Point :417 °F at 760 mm Hg (NTP, 1992)
Solubility :9.99 M
Density :1.085 at 68 °F (NTP, 1992)
Chemical Classes :Nitrogen Compounds -> Nitrosamines
Use Classification :Fire Hazards -> Carcinogens, Flammable - 2nd degree
Hazard Class :Acute Tox. 4 (100%)
EC Number :213-218-8
UNII :SZ4J5WK201
NCI Thesaurus Code :C44424
MeSH Entry Terms :N Nitrosopyrrolidine
Other Synonyms :1-Nitrosopyrrolidine
Removed Synonyms :N Nitrosopyrrolidine
Vapor Pressure : 0.06 mmHg
Other Experimental Properties :Can be steam-distilled; strong oxidants (peracids) oxidize it to corresponding nitramine; can be reduced to corresponding hydrazine and/or amine; relatively resistant to hydrolysis, but can be split by hydrogen bromide in acetic acid
Disposal Methods :Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U180, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Interactions :... Oral administration of ethanol (6.3 g/kg bw) 1 hr prior to administration of ... N-nitrosopyrrolidine resulted in a substantial reduction of genotoxicity that was more pronounced in the liver as compared to lungs, spleen, kidneys and blood. However, when the same ethanol dose was given 26 hr before ... N-nitrosopyrrolidine, an increase of DNA damage was found, that was, in most cases, higher in the kidneys than in the liver. Significant enhancement of genotoxic activity was also measured in lungs and spleen, whereas only a marginal increase was detectable in the blood. Repeated administration of smaller ethanol doses (2.0 g/kg body wt at 12 hr intervals) for 4 days caused a comparable increase. Similar enhancement of genotoxicity was also measured when acetone (3.5 g/kg) was given orally 15 hr before nitrosamine administration. The stimulating effect of ethanol was dose dependent and was absent when the alcohol was administered 60 hr prior to the nitrosamine. ...
Antidoteand Emergency Treatment :Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Nitrates, nitrites, and related compounds/
Human Toxicity Excerpts :/GENOTOXICITY/ Liver S9 fractions were prepared from male and female Syrian Golden hamsters and Sprague-Dawley rats, 1, 3, 6, and 12 mo of age, which were either uninduced (corn-oil treated) or induced with Aroclor 1254 suspended in corn oil. These preparations were compared at varying protein levels for their ability to metabolize ... nitrosopyrrolidine ... to products mutagenic to Salmonella typhimurium. ... The greatest number of revertant colonies with nitrosopyrrolidine occurred with preparations from male hamsters. A decrease in numbers of revertant colonies with increasing age was observed with the S9 preparation from Arcolor-treated male rats. ... The only nitrosamine mutagenic with human liver S9 was nitrosopyrrolidine. All of the human preparations metabolized this carcinogen at similar levels. ...
Non Human Toxicity Excerpts :/LABORATORY ANIMALS: Acute Exposure/ The effects of the carcinogenic N-nitrosamine N-nitrosopyrrolidine (NPYR) and the non-carcinogenic N-nitrosamino acid N-nitrosoproline on (3)H-thymidine incorporation into DNA were evaluated in various organs of male C57BL mice. The N-nitroso compounds were given intraperitoneally 24 hrs before sacrifice in equimolar amounts (148 mumol/kg body weight). Two hours before the mice were killed, they were given an intraperitoneal injection of (3)H-thymidine. NPYR, but not N-nitrosoproline, induced a tissue-specific inhibition of (3)H-thymidine incorporation into DNA. The inhibition occurred only in organs reported to be involved in the biotransformation of NPYR, ie, the liver, lung, and nasal mucosa. Daily oral consumption of ethanol (1.8 ml 30% ethanol for 30 days) had no effects in itself on (3)H-thymidine incorporation, but resulted in an enhancement of the inhibitory action of NPYR in the lung and nasal mucosa.
Exact Mass :100.063662883
InChI :InChI=1S/C4H8N2O/c7-5-6-3-1-2-4-6/h1-4H2
InchIKey :WNYADZVDBIBLJJ-UHFFFAOYSA-N
Canonical SMILES :C1CCN(C1)N=O
Isomeric SMILES :C1CCN(C1)N=O
Hazard Summary :Danger of cutaneous absorption; MAC-2 (considered to be carcinogenic for man because sufficient data from long-term animal studies or limited evidence from animal studies substantiated by evidence from epidemiological studies indicate that it can make a significant contribution to cancer risk); [MAK] May cause irritation; Causes injury to liver, lungs, and blood in high-dose animal studies; [MSDSonline]
Product Description :N-Nitrosopyrrolidine is a member of pyrrolidines.
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 2-3 Weeks
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 2-3 Weeks
Taxes : Not Applicable
Refund Policy : 30-days money back


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