Gliclazide EP Impurity A

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Catalog Number : CS-T-44602
CAS Number : 70-55-3
Status : Available for immediate dispatch
Category : Impurities
Purity : Not less than 90 %
Molecular Weight : 171.22 mol/g
Molecular Formula : C₇H₉NO₂S
Therapeutic : Anti-Diabetic
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Status : Available for immediate dispatch
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Hazardous Compound : No

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Application : 4-Tolylsulfonamide is a carbonic anhydrase inhibitor used the synthesis of antiglaucoma and anticancer drugs.
Payment mode : Credit / Debit / Purchase Order
Taxes : All prices are inclusive taxes
Refund Policy : 30 days money back guarantee
References : "Vullo, D, et al,: Bioorg, Med, Chem, Lett,, 15, 963 (2005); Vullo, D, et al,: Bioorg, Med, Chem, Lett,, 15, 971 (2005); "
Canonical SMILES : CC1=CC=C(C=C1)S(=O)(=O)N
Isomeric SMILES : CC1=CC=C(C=C1)S(=O)(=O)N
InChI : InChI=1S/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)
InchIKey : LMYRWZFENFIFIT-UHFFFAOYSA-N
IUPAC Name : 4-methylbenzenesulfonamide
Exact Mass : 171.03539970
Color : Monoclinic plates (w+2)
Melting Point : 138.5 °C
Boiling Point : BP: 214 °C at 10 mm Hg
Solubility : 0.02 M
Chemical Classes : Nitrogen Compounds -> Sulfonamides
Industry Uses : Paint additives and coating additives not described by other categories
Consumer Uses : Paints and coatings
Hazard Class : Skin Irrit. 2 (14.68%)
Description : Toluene-4-sulfonamide is a sulfonamide that is benzenesulfonamide bearing a methyl group at position 4.
Disposal Methods : SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
EC Number : 200-741-1
Vapor Pressure : 0.000096 [mmHg]
Toxicity Summary : IDENTIFICATION AND USE: p-Toluenesulfonamide is a solid. It is used in organic synthesis, in plasticizers and resins, and as a fungicide and mildewicide in paints and coatings. It has been used as experimental therapy. HUMAN STUDIES: It is known as a common contact allergen. ANIMAL STUDIES: No treatment-related effects were observed in a 90 day feeding study on dogs exposed to doses up to 3000 mg/kg feed of a mixture of p-toluenesulfonamide (68%) and ortho-toluenesulfonamide (32%), equivalent to 75 mg/kg bw/day. In a 90 day feeding study, rats were exposed to diets containing 0, 300, 1000 or 3000 mg/kg feed of mixture of p-toluenesulfonamide (68%) and ortho-toluenesulfonamide (32%), equivalent to approximately 15, 50 or 150 mg/kg bw/day. A slight reduction of weight gain and food consumption was present at 3000 mg/kg feed as the only treatment-related effects. Pregnant rats were treated by gavage on gestational days 6-15 with 0, 50, 250, or 500 mg/kg bw of a mixture of p-toluenesulfonamide (68%) and ortho-toluenesulfonamide (32%). At 250 and 500 mg/kg bw maternal weight gain was significantly reduced during the treatment period. At the same dose levels, postimplantation loss demonstrated a dose-related increase and fetal weight was reduced. No teratogenic effect was observed. p-Toluenesulfonamide was studied for mutagenic potential with Salmonella typhimurium/microsome test, basic-test in Drosophila melanogaster, and micronucleus test in mice. No test revealed mutagenic activity.
Antidoteand Emergency Treatment : /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
Human Toxicity Excerpts : /HUMAN EXPOSURE STUDIES/ Common contact allergen. /Toluene sulfonamide resins, from table/

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