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Romidepsin



Chemical Properties of 'Romidepsin'

CAT No. :

CS-T-61146
CAS Registry No. : 128517-07-7
Category : API Standards
Molecular Weight: 540.7
Molecular Formula : C₂₄H₃₆N₄O₆S₂



OTHER INFORMATION of 'Romidepsin'
Purity : Not less than 95 %
Therapeutic : Anti-Cancer / Oncology
Purity : Not less than 95 %
Therapeutic : Anti-Cancer / Oncology
IUPAC Name :(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Applicationnotes :Romidepsin is a Histone Deacetylase Inhibitor.
Synonym :NA
References :"Ueda, H,, et al,: J, Antibiot,, 47, 301 (1994), Weidle, U,, et al,: Anticancer Res,, 20, 1471 (2000), Kitazono, M,, et al,: Cancer Res,, 61, 6328 (2001), Sandor, V,, et al,: Clin, Cancer Res,, 8, 718 (2002),"
Smileys :O=C(N/C(C(N[C@@](C(O1)=O)([H])C(C)C)=O)=C\C)[C@](CSSCC/C=C/[C@]1([H])CC2=O)([H])NC([C@H](N2)C(C)C)=O
Appearance :White to off white solid
Use Classification :Human drugs -> Orphan -> Istodax -> EMA Drug Category
Hazard Class :Acute Tox. 3 (100%)
EC Number :686-179-1
UNII :CX3T89XQBK
NCI Thesaurus Code :C1544
RXCUI :877510
MeSH Entry Terms :FK228
Other Synonyms :Romidepsin
Removed Synonyms :Cryptophycins
Label Ingredient : ROMIDEPSIN
NDC Code :0703-4004-01, 59572-961-10, 59572-962-10, 59572-972-02, 59572-973-02, 59572-983-01, 59572-984-01, 63323-922-03, 63323-925-17, 63323-926-88
Toxicity Summary :Risk factor D in pregnancy. It is not known if romidepsin is excreted in breast milk. Due to the potential for serious adverse reactions in the nursing infant, the manufacturer recommends a decision be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of treatment to the mother. The majority of patients receiving romidepsin experience nausea, vomiting, and anorexia.
Hepatotoxicity :In clinical trials of romidepsin in patients with CTLC and PTLC, the rates of serum enzyme elevations during therapy ranged from 7% to 20%, but the abnormalities were usually transient and mild and did not require dose modifications. Serum ALT elevations above 5 times ULN occurred in 6% of patients. In the preregistration clinical trials of romidepsin, there were no reports of hepatitis, jaundice or clinically apparent liver injury among the treated subjects. Romidepsin has had limited clinical use, but there is no evidence that it is associated with significant liver injury.
Drug Induced Liver Injury :romidepsin
Protein Binding :Highly protein bound in plasma (92%-94%)
Exact Mass :540.20762723
InChI :InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
InchIKey :OHRURASPPZQGQM-GCCNXGTGSA-N
Canonical SMILES :CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C
Isomeric SMILES :C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C
Product Description :Romidepsin is a cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail. It has a role as an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a cyclodepsipeptide, an organic disulfide and a heterocyclic antibiotic.
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 2-3 Weeks
Taxes : Not Applicable
Refund Policy : 30-days money back
Custom Duty : Applicable
Port of Loading : Canada
Expected Dispatch : 2-3 Weeks
Taxes : Not Applicable
Refund Policy : 30-days money back


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