Trimethylamine (~25 wt. % solution in methanol)

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Catalog Number : CS-T-87767
CAS Number : 75-50-3
Status : Available for immediate dispatch
Category : Intermediates, Amides
Industry : Flavours And Fragrances
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Canonical SMILES : CN(C)C
Isomeric SMILES : CN(C)C
InChI : InChI=1S/C3H9N/c1-4(2)3/h1-3H3
InchIKey : GETQZCLCWQTVFV-UHFFFAOYSA-N
Related CAS : 20230-89-1 (hydriodide)
IUPAC Name : N,N-dimethylmethanamine
Exact Mass : 59.073499291
Color : Colorless gas at room temperature
Odor : Pungent, fishy, ammoniacal
Melting Point : -178.8 °F (USCG, 1999)
Boiling Point : 37.2 °F at 760 mm Hg (USCG, 1999)
Solubility : 15.06 M
Density : 0.633 at 68 °F (USCG, 1999)
Chemical Classes : Nitrogen Compounds -> Amines, Aliphatic
Use Classification : Food additives -> Flavoring Agents
Industry Uses : Intermediates
Consumer Uses : Non-TSCA use
Hazard Class : Flam. Gas 1 (25.97%)
Description : Trimethylamine is a tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group. It has a role as a human xenobiotic metabolite and an Escherichia coli metabolite. It is a tertiary amine and a member of methylamines. It is a conjugate base of a trimethylammonium.
Disposal Methods : SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
EC Number : 200-875-0
Vapor Pressure : 1487.83 mm Hg at 70 °F (USCG, 1999)
Toxicity Summary : IDENTIFICATION AND USE: Trimethylamine (TMA) is a colorless gas. It is used in the manufacture of quaternary ammonium compounds, as an insect attractant, as a warning agent for natural gas, and as a corrosion inhibitor. It is also a synthetic flavor ingredient. HUMAN STUDIES: Potential symptoms of overexposure to TMA are irritation of the eyes, skin, nose, throat, and respiratory system, as well as cough, dyspnea, delayed pulmonary edema, blurred vision, corneal necrosis, and skin burns. Direct contact with liquid may cause frostbite. Trimethylaminuria or 'fish odor syndrome' described in human patients is due to excessive excretion into body fluids and breath of TMA derived from the enterobacterial metabolism of dietary precursors. Comparison of the effects of administration of antibiotics (metronidazole, amoxicillin, neomycin) on gut bacterial production of TMA from choline showed they all reduced TMA production to a limited extent, with neomycin being most effective. ANIMAL STUDIES: Tests of single drops of aqueous solution applied to animal eyes have shown that 1% solution causes severe irritation, 5% causes hemorrhagic conjunctivitis, and 16.5% causes a severe reaction with conjunctival hemorrhages, corneal edema, and opacities, followed by some clearing but much vascularization. TMA is an emetic in dogs at an oral dose of 1000 mg/kg. At the same oral dose, TMA induced emesis and produced anorexia, paralysis, and death in pigs within 48 hours. In a repeated inhalation exposure study, groups of rats were exposed 6 hr/day, 5 days/week for 2 weeks at 0, 75, 250, or 750 ppm TMA vapor. After 10 exposures, histopathologic examination revealed concentration-dependent degenerative changes in the nasal olfactory and respiratory mucosa at all exposure levels. A similar degeneration of the tracheal mucosa was observed at 250 and 750 ppm. In mice, intraperitoneal injections (daily from day 1 to 17 of gestation) of TMA at 2.5 and 5 mmol/kg/day significantly decreased fetal body weight but not the placental weight or maternal body weight gain, however, 5 of 11 mice treated with 5 mmol/kg TMA died. TMA was tested in as many as 5 Salmonella typhimurium strains (TA 1535, TA 1537, TA 97, TA 98, and TA 100) in the presence and absence of metabolic activation. TMA was negative in these tests at doses of 0.010, 0.033, 0.10, 0.33 and 1.0 mg/plate. The highest ineffective dose tested in any S. typhimurium strain was 1.000 mg/plate. ECOTOXICITY STUDIES: TMA caused inhibition to nitrifiers. Inhibition tests were conducted by using the oxygen utilization rate test with an enhanced nitrifier culture.
Antidoteand Emergency Treatment : Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/
Human Toxicity Excerpts : /SIGNS AND SYMPTOMS/ Potential symptoms of overexposure to trimethylamine are irritation of eyes, skin, nose, throat, respiratory system; cough, dyspnea, delayed pulmonary edema; blurred vision, corneal necrosis; skin burns; direct contact with liquid may cause frostbite.

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