Mono-POC Isopropyl Tenofovir
| Product Name | Mono-POC Isopropyl Tenofovir |
|---|---|
| Alternate Names | Tenofovir Impurities, Impurities of Tenofovir |
| CAT No. | CS-O-10863 |
| CAS No. | 1246812-40-7 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 445.41 g/mol |
| Mol. For. | C₁₇H₂₈N₅O₇P |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Tenofovir |
| Purity | For long term usage store at -20?C |
| Therapeutic | Antiretroviral / Anti-HIV |
| Smileys | C[C@@H](OC[P](OCOC(OC(C)C)=O)(OC(C)C)=O)CN1C2=NC=NC(N)=C2N=C1 |
| Canonical Smiles | CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC(C)C |
| InchIKey | IHJDJJPKNNEZLC-SGSXECEGSA-N |
| Inchl | InChI=1S/C17H28N5O7P/c1-11(2)28-17(23)25-9-27-30(24,29-12(3)4)10-26-13(5)6-22-8-21-14-15(18)19-7-20-16(14)22/h7-8,11-13H,6,9-10H2,1-5H3,(H2,18,19,20)/t13-,30?/m1/s1 |
| IUPAC | [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-propan-2-yloxyphosphoryl]oxymethyl propan-2-yl carbonate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Mono-POC Isopropyl Tenofovir is a potent nucleotide reverse transcriptase inhibitor that is used for the treatment of HIV-1 infection. It is a prodrug of tenofovir, which is converted into its active form, tenofovir diphosphate, in vivo. Mono-POC Isopropyl Tenofovir is designed to have improved pharmacokinetic properties, which allows for once-daily dosing and better patient compliance.
Chemically, Mono-POC Isopropyl Tenofovir is an ester of isopropyl alcohol and tenofovir. The isopropyl group in the molecule enhances its lipophilicity, which allows for better absorption and distribution in the body. The prodrug is rapidly hydrolyzed by esterases in the blood, releasing tenofovir.
Tenofovir diphosphate inhibits the activity of reverse transcriptase, which is essential for the replication of HIV-1. It competes with the natural substrate, deoxyadenosine triphosphate, and incorporates itself into the growing DNA chain, leading to chain termination. Tenofovir diphosphate also inhibits the activity of viral DNA polymerase, which further reduces viral replication.
Mono-POC Isopropyl Tenofovir is administered orally and is rapidly absorbed from the gastrointestinal tract. It has a long half-life of approximately 17 hours, which allows for once-daily dosing. The drug is primarily eliminated via the kidneys, and dosage adjustments are necessary in patients with renal impairment. Overall, Mono-POC Isopropyl Tenofovir is an effective and well-tolerated treatment for HIV-1 infection.
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Related Compounds
Tenofovir Impurity 65 | Tenofovir alafenamide lactose Millard Reaction product-2 | Ethyl Tenofovir Impurity | Tenofovir Alanine ester impurity | Tenofovir Alafenamide Enantiomer | MOC-POC Tenofovir | Mono-POC Tenofovir 6-Isopropyl Carbamate | Tenofovir Alfenamide Amadori Rearrangement product | Tenofovir Related Compound 14 | Desmethyl Tenofovir Disoproxil Fumarate | Tenofovir alafenamide (RRS) diasteroisomer | Tenofovir Related Compound 5 | Mono-POC Methyl Tenofovir Fumarate (Mixture of Diastereomers) | Tenofovir impurity C fumarate salt | Tenofovir Impurity 59 | Tenofovir Alafenamide (RSR) Diasteroisomer | Tenofovir alafenamide lactose Millard Reaction product-3 | Tenofovir Isopropyl Carbamate | Tenofovir Disoproxil T8 Impurity | Tenofovir Disoproxil T5 Impurity | Diisopropyl Tenofovir Fumarate | Tenofovir Disoproxil Fumarate USP RC J | TenofovirDisoproxil Ethyl fumarate Impurity | Tenofovir Mixed dimer | Tenofovir DP-V | Tenofovir Alafenamide Glycosamine product | Tenofovir EP Impurity C Succinate | Tenofovir Alafenamide Dimer impurity | nPOC-POC Tenofovir Fumarate | Isopropyl Tenofovir | Tenofovir disoproxil impurity L fumarate | Tenofovir Impurity 62 | TAF methyl ester | Tenofovir Mono-POC methyl ester | Tenofovir Impurity 35 | Diethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers) | nPOC-POC Tenofovir | Tenofovir Alafenamide Racemic D Isomer | TAF Propyl ester Impurity | Tenofovir alafenamide Impurity 1 | Tenofovir Disoproxil T7 Impurity | Tenofovir Disoproxil Isopropoxycarbonyl | Tenofovir Alafenamide N-hydroxy methyl impurity | Tenofovir diphosphate | Tenofovir Impurity 59-D6 | tenofovir related impurity | MOC-POC Tenofovir Fumarate | Tenofovir Mono POC Dimer Diethyl amine salt | Tri-POC Tenofovir Dimer | Mono poc-isopropyl-Tenofovir fumarate salt | Tenofovir Bis ((R)-9-(2-Hydroxypropyl)adenine) dimer Acetate salt | Tenofovir Impurity 36 (RSR) 2,3-dihydroxysuccinate salt | Tenofovir alafenamide Impurity 3 | Tenofovir Diphenyl HemiFumarate salt | Tenofovir alafenamide Methyl ester impurity | Tenofovir alafenamide Impurity 5 | Tenofovir Alafenamide Dimer Impurity II | Tenofovir Impurity 39 (RRR) 2,3-dihydroxysuccinate salt | Tenofovir DP-IV | Tenofovir Disoproxil Fumarate Impurity | Tenofovir disoproxil phosphate | Tenofovir Disoproxil Dimer | Mono ester impurity (Tenofovir) | Tenofovir disoproxil impurity L | TAF SRS diastereomer | Tenofovir Impurity 89 | Tenofovir alafenamide monofumarate | Tenofovir Disoproxil (S)-Isomer fumarate salt | Diethylaminocarboxymethyl POC Tenofovir Fumarate | Desmethyl Tenofovir disoproxil |