Tenofovir Disoproxil (S)-Isomer fumarate salt

Tenofovir Disoproxil (S)-Isomer fumarate salt, also known as Tenofovir DF, is a prescription medication used to treat HIV-1 infection in adults and children weighing at least 17 kg. It is an antiviral drug that works by inhibiting the activity of the reverse transcriptase enzyme, which is essential for the replication of the virus. This drug does not cure HIV-1 infection, but it helps to reduce the amount of the virus in the body, improve immune system function, and prevent the development of acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses. Tenofovir DF is available in tablet form and is taken orally, usually once a day, with or without food. The recommended dose depends on the patient's age, weight, and medical condition, and should be determined by a healthcare provider. The drug is generally well-tolerated, but some side effects may occur, including nausea, vomiting, diarrhea, headache, dizziness, and fatigue. Rare but serious side effects may include kidney problems, lactic acidosis, and liver problems. Chemically, Tenofovir DF is an oral prodrug of Tenofovir, which is a nucleotide analog reverse transcriptase inhibitor. The (S)-isomer of Tenofovir DF is preferred because it has higher antiviral activity and lower toxicity than the (R)-isomer. The fumarate salt form of Tenofovir DF is used to improve its solubility and stability, allowing for better absorption and distribution in the body. Overall, Tenofovir DF is an important drug in the treatment of HIV-1 infection, and its efficacy and safety have been demonstrated in numerous clinical trials.