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Tenofovir alafenamide Impurity 1
| Chemical Name | Tenofovir alafenamide Impurity 1 |
|---|---|
| CAT No. | CS-O-15852 |
| CAS Registry# | 851456-00-3 |
| Status |
|
| Category | Impurities |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| Controlled | No |
Additional Information
| Controlled | No |
|---|---|
| Parent API | Tenofovir |
| Therapeutic | Antiretroviral / Anti-HIV |
| Smileys | C[C@@H](OC[P](N[C@@H](C)C(OC(C)C)=O)(O)=O)CN1C2=NC=NC(N)=C2N=C1 |
| Hazardous | No |
Usage and description
Tenofovir alafenamide Impurity 1 is a chemical compound that is used in the pharmaceutical industry as a reference standard to determine the purity of Tenofovir alafenamide (TAF), a medication used to treat Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) infections. TAF is a prodrug of Tenofovir, which is an antiviral medication. TAF is metabolized in the body to Tenofovir, which then inhibits the viral reverse transcriptase enzyme, thereby preventing the replication of the virus.
Tenofovir alafenamide Impurity 1 is a synthetic compound that is chemically known as 3-((R)-1-(6-amino-9H-purin-9-yl)propan-2-yloxy)-5-methylbenzonitrile. It is a white or off-white crystalline powder that has a molecular weight of 323.32 grams per mole. Tenofovir alafenamide Impurity 1 is soluble in organic solvents such as methanol, ethanol, and dimethyl sulfoxide.
The usage of Tenofovir alafenamide Impurity 1 is primarily in quality control and analytical testing of TAF. It is used as a standard reference material for high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) analysis. The purity of TAF is determined by comparing the retention time and peak area of Tenofovir alafenamide Impurity 1 with that of the TAF sample.
In conclusion, Tenofovir alafenamide Impurity 1 is an important reference standard for the quality control of TAF, which is a widely used medication for the treatment of HIV and HBV infections. Its chemical properties and usage in analytical testing make it a valuable tool for pharmaceutical companies and research institutions.
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