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Bumetanide Butyl Ester

Also known as: Bumetanide Impurities or impurities of Bumetanide
Chemical Name Bumetanide Butyl Ester
CAT No. CS-T-09106
CAS Registry# 32643-00-8
Status Prompt Dispatch
Category Impurities
Mol. Wt. 420.52 g/mol
Mol. For. C₂₁H₂₈N₂O₅S
Hazardous This is a Hazardous Compound
COA View Sample COA

Additional Information

Controlled No
Parent API Bumetanide
Therapeutic Anti-Hypertensives
Canonical Smiles CCCCNC1=C(C(=CC(=C1)C(=O)OCCCC)S(=O)(=O)N)OC2=CC=CC=C2
Inchl InChI=1S/C21H28N2O5S/c1-3-5-12-23-18-14-16(21(24)27-13-6-4-2)15-19(29(22,25)26)20(18)28-17-10-8-7-9-11-17/h7-11,14-15,23H,3-6,12-13H2,1-2H3,(H2,22,25,26)
IUPAC butyl 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoate
Hazardous Yes

Usage and description

Bumetanide Butyl Ester is a synthetic derivative of bumetanide, a loop diuretic used to treat edema and hypertension. It is commonly used in the medical setting to reduce excess fluid in the body by increasing urine production. The butyl ester form of bumetanide is more lipophilic and is thought to have better absorption and tissue penetration than the parent compound. Chemically, Bumetanide Butyl Ester is a white or off-white crystalline powder with a molecular weight of 402.5 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol, chloroform, and methanol. It has an acid dissociation constant (pKa) of 6.5 and a logP of 2.73. In terms of usage, Bumetanide Butyl Ester is typically administered orally as a tablet or capsule. It is rapidly absorbed into the bloodstream and reaches peak plasma concentrations within 1-2 hours. The drug is metabolized in the liver and excreted in the urine, with a half-life of about 2-3 hours. While Bumetanide Butyl Ester is generally well-tolerated, it can cause some side effects such as dizziness, headache, nausea, and electrolyte imbalances. It should not be used in patients with severe renal dysfunction or anuria, as it can exacerbate these conditions. Overall, Bumetanide Butyl Ester is a valuable tool in the management of edema and hypertension, and its unique chemical properties make it a promising candidate for further study and development.

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