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Losartan Potassium EP Impurity H

Also known as: Losartan Impurities or impurities of Losartan
Chemical Name Losartan Potassium EP Impurity H
CAT No. CS-T-62580
CAS Registry# 133909-99-6
Status Prompt Dispatch
Category Impurities
Mol. Wt. 665.23 g/mol
Mol. For. C₄₁H₃₇ClN₆O
Hazardous This is a Hazardous Compound
COA View Sample COA

Additional Information


Controlled No
Parent API Losartan
Smileys OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN(N=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7
Canonical Smiles CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN(N=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)CO)Cl
InchIKey QQPGGBNMTNDKEY-UHFFFAOYSA-N
Inchl InChI=1S/C41H37ClN6O/c1-2-3-23-38-43-39(42)37(29-49)47(38)28-30-24-26-31(27-25-30)35-21-13-14-22-36(35)40-44-46-48(45-40)41(32-15-7-4-8-16-32,33-17-9-5-10-18-33)34-19-11-6-12-20-34/h4-22,24-27,49H,2-3,23,28-29H2,1H3
IUPAC [2-butyl-5-chloro-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Hazardous Yes


Usage and description


Losartan Potassium EP Impurity H is a chemical compound that is used in the pharmaceutical industry as an impurity reference standard for Losartan Potassium. Losartan Potassium is a medication that is used to treat high blood pressure and other cardiovascular diseases. Losartan Potassium EP Impurity H is a byproduct that is formed during the synthesis of Losartan Potassium and it is important to ensure that its presence is within acceptable limits to maintain the efficacy and safety of the medication. Chemically, Losartan Potassium EP Impurity H is known as (2-but-1-enyl-4-chloro-5-formyl-1H-pyrrole-3-carbonyl)-L-proline, and its molecular formula is C14H16ClN2O3. It is a yellow to orange crystalline powder with a melting point of 160-164°C. It is soluble in organic solvents like methanol, ethanol, and acetonitrile, but it is insoluble in water. The usage of Losartan Potassium EP Impurity H involves its inclusion in the testing and validation of analytical methods used to determine the purity and quality of Losartan Potassium. It is also used as a reference standard in the development and manufacturing of Losartan Potassium. The chemical information of Losartan Potassium EP Impurity H is important for ensuring that the medication is safe and effective for use in patients with high blood pressure and other cardiovascular diseases.

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