2’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine-13C,15N2

2’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine-13C,15N2 is a modified form of the nucleoside cytidine. This compound is used in scientific research as a labeled analogue for studying the metabolism, pharmacokinetics, and pharmacodynamics of cytidine derivatives. The labeled isotopes, 13C and 15N, allow for the tracking and identification of the compound in complex biological systems. In terms of chemical information, 2’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine-13C,15N2 has a molecular formula of C23H17F2N4O5 and a molecular weight of 494.40 g/mol. It is a white to off-white powder that is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). This compound is a prodrug that requires activation by cellular kinases to generate the active metabolite, 2’-deoxy-2’,2’-difluorocytidine triphosphate (dFdCTP). dFdCTP inhibits the activity of DNA polymerase and induces DNA chain termination, resulting in the inhibition of DNA synthesis and cell death. This mechanism of action makes it a potent antiviral and anticancer agent. In summary, 2’-Deoxy-3’,5’-di-O-benzoyl-2’,2’-difluorocytidine-13C,15N2 is a useful tool for understanding the behavior of cytidine derivatives in complex biological systems and for the development of new antiviral and anticancer agents.