Sofosbuvir 3’,5’-Bis-(S)-phosphate
| Product Name | Sofosbuvir 3’,5’-Bis-(S)-phosphate |
|---|---|
| Alternate Names | Sofosbuvir Impurities, Impurities of Sofosbuvir |
| CAT No. | CS-T-84999 |
| CAS No. | 1337482-17-3 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 798.69 g/mol |
| Mol. For. | C₃₄H₄₅FN₄O₁₃P₂ |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Sofosbuvir |
| Therapeutic | Antiretroviral / Anti-HIV |
| Smileys | C[C@H](NP(OC1=CC=CC=C1)(O[C@@H]2[C@@H](COP(OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)O[C@@H](N(C(N4)=O)C=CC4=O)[C@@]2(F)C)=O)C(OC(C)C)=O |
| Canonical Smiles | CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)OP(=O)(NC(C)C(=O)OC(C)C)OC3=CC=CC=C3)OC4=CC=CC=C4 |
| InchIKey | WVORGVRHMQFKTN-ACVYKXDBSA-N |
| Inchl | InChI=1S/C34H45FN4O13P2/c1-21(2)47-30(41)23(5)37-53(44,50-25-14-10-8-11-15-25)46-20-27-29(34(7,35)32(49-27)39-19-18-28(40)36-33(39)43)52-54(45,51-26-16-12-9-13-17-26)38-24(6)31(42)48-22(3)4/h8-19,21-24,27,29,32H,20H2,1-7H3,(H,37,44)(H,38,45)(H,36,40,43)/t23-,24-,27+,29+,32+,34+,53?,54?/m0/s1 |
| IUPAC | propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyl-3-[[[(2S)-1-oxo-1-propan-2-yloxypropan-2-yl]amino]-phenoxyphosphoryl]oxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Sofosbuvir 3’,5’-Bis-(S)-phosphate is a prodrug of Sofosbuvir, which is a potent inhibitor of the hepatitis C virus (HCV) polymerase enzyme. Sofosbuvir has revolutionized the treatment of HCV, which affects millions of people worldwide. The drug is generally well-tolerated and has high efficacy rates in curing HCV infections.
Sofosbuvir 3’,5’-Bis-(S)-phosphate is a phosphorylated form of Sofosbuvir, which increases its solubility and bioavailability. It is rapidly converted to Sofosbuvir in the body and the active drug is then able to enter hepatocytes and inhibit the replication of HCV. Sofosbuvir 3’,5’-Bis-(S)-phosphate has shown to be effective against all genotypes of HCV and has minimal side effects.
The chemical structure of Sofosbuvir 3’,5’-Bis-(S)-phosphate includes a phosphorus atom, which is essential for its activity. The drug works by inhibiting the HCV RNA polymerase enzyme, which is crucial for the replication of the virus. It acts as a nucleotide analogue, which means it can mimic the building blocks of RNA and interfere with the replication process.
In conclusion, Sofosbuvir 3’,5’-Bis-(S)-phosphate is a prodrug of the highly effective HCV inhibitor Sofosbuvir. Its phosphorylation increases its solubility and bioavailability and it works by inhibiting the HCV RNA polymerase enzyme. The drug has revolutionized the treatment of HCV and has high efficacy rates with minimal side effects.
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Related Compounds
Sofosbuvir impurity 9 | Sofosbuvir impurity 32 | Ethyl 2-(triphenylphosphoranylidene)propanoate | Sofosbuvir impurity 43 | Sofosbuvir impurity 12 | Sofosbuvir Des L-Alanine | Sofosbuvir impurity 6 | Sofosbuvir impurity 5 | N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine-1-methylethyl ester | Sofosbuvir L-alanitate (Mixture of Diasteriomers) | Sofosbuvir Impurity 11 | Sofosbuvir Degradation Impurity 1 | Sofosbuvir Impurity | O-Desphenyl Sofosbuvir | Sofosbuvir Dimer | Ethyl sofosbuvir | L-Alanine Isopropyl Ester Hydrochloride | Isopropyl N-[chloro(phenoxy)phosphoryl]-L-alaninate | Sofosbuvir D-Alaninate | Chloro Sofosbuvir Desphosphate | Sofosbuvir impurity 19 | Sofosbuvir impurity 3 | Sofosbuvir Chloro Analogue | Chloro (R)-Phosphoryl Sofosbuvir | Sofosbuvir intermediate isomer Impurity | Sofosbuvir Impurity D |