D-myo-Inositol-2,3,5-triphosphate (ammonium salt)
PHOSPHOINOSITOLS    
Availability: Available - Dispatch by : 24-Dec-2019 5:00 PM
CAT No. CS-AU-00025
Category Phosphoinositols
CAS 1246303-11-6
Mol. Weight 522.3 g/mol
View COA View MSDS
Product Description
Stock Status Available - Dispatch by : 24-Dec-2019 5:00 PM
Synonyms ammonium (1S,2R,3S,4R,5S,6S)-3,5,6-trihydroxycyclohexane-1,2,4-triyl tris(hydrogenphosphate)
Purity (%) >98%
Application Notes D-myo-Inositol-2,3,5-triphosphate (ammonium salt) (Ins(2,3,5)P3(ammonium salt)) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.1,2 The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3,4 Binding Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4,5 Ins(2,3,5)P3(ammonium salt) (tested as a racemic mixture) is 500-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopusoocytes.6
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


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c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated


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