Availability: Compound under re-stock / certification. Please enquire for exact delivery date
CAT No. CS-CM-00016
Category Metabolites
Parent API Apoptolidin
CAS 194874-06-1
Mol. Weight 1129.37 g/mol
Mol. Formula C58H96O21
View COA View MSDS
Product Description
Stock Status Compound under re-stock / certification. Please enquire for exact delivery date
Synonyms (3E,5E,7E,9R,10R,11E,13E,17S,18S,20S)-20-[(R)-{(2R,3R,4S,5R,6R)-2,4-Dihydroxy-6-[(2R)-2-{[(2R,4S,5S,6S)-4-hydroxy-5-{[(2S,4R,5R,6R)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4,6-dimeth yltetrahydro-2H-pyran-2-yl]oxy}-3-methoxypropyl]-3,5-dimethyltetrahydro-2H-pyran-2-yl}(hydroxy)methyl]-10-{[(2R,3S,4S,5R,6S)-3,4-dihydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-17-hydroxy-18 -methoxy-3,5,7,9,13-pentamethyloxacycloicosa
Application Notes Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action. Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues.
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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Related Results

- API Standards of Apoptolidin
- Stable Isotopes of Apoptolidin
- Metabolites of Apoptolidin
- Impurities of Apoptolidin
- Glucuronides of Apoptolidin
- Intermediates of Apoptolidin

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