Piericidin A
Availability: Dispatch by : 5-Nov-2019 5:00 PM
CAT No. CS-CM-00149
Category Metabolites
Parent API Piericidin
CAS 2738-64-9
Mol. Weight 415.56 mol/g
Mol. Formula C25H37NO4
Product Description
Pubchem Id 6437838
Stock Status Dispatch by : 5-Nov-2019 5:00 PM
Synonyms 2-((2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl)-5,6-dimethoxy-3-methylpyridin-4(1H)-one
Application Notes Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces species. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUODNUOB interfaceEvidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I. Prieur I. et al. Biochim.
References Kroiss et al.., Nature Chemical Biology, 2010
Smileys CC=C(C)C(C(C)C=C(C)C=CCC(=CCC1=C(C(=O)C(=C(N1)OC)OC)C)C)O
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Quality Assurance

ISO 9001:2005
ISO Guide 34:2009
ISO/IEC 17025:2005
OHSAS 18001:2007
ISO 14001:2005
NIST Calibrated
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