Piericidin A
Availability: Compound under re-stock / certification. Please enquire for exact delivery date
CAT No. CS-CM-00149
Category Metabolites
Parent API Piericidin
CAS 2738-64-9
Mol. Weight 415.56 g/mol
Mol. Formula C25H37NO4
View COA View MSDS
Product Description
Stock Status Compound under re-stock / certification. Please enquire for exact delivery date
Synonyms 2-((2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl)-5,6-dimethoxy-3-methylpyridin-4(1H)-one
Application Notes Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces species. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUODNUOB interfaceEvidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I. Prieur I. et al. Biochim.
References Kroiss et al.., Nature Chemical Biology, 2010
Pubchem Id 6437838
Smiles CC=C(C)C(C(C)C=C(C)C=CCC(=CCC1=C(C(=O)C(=C(N1)OC)OC)C)C)O
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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Related Results

- API Standards of Piericidin
- Stable Isotopes of Piericidin
- Metabolites of Piericidin
- Impurities of Piericidin
- Glucuronides of Piericidin
- Intermediates of Piericidin

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