Validamycin A
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Dispatch to US by: 29-May-2020 5:00 PM

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CAT No. CS-CM-00183
Category Metabolites
Parent API Validamycin
CAS 37248-47-8
Mol. Weight 497.49 g/mol
Mol. Formula C20H35NO13
View COA View MSDS
Product Description
Stock Status In-Stock
Dispatch to US by: 29-May-2020 5:00 PM
Synonyms (2R,3R,4S,5S,6R)-2-(((1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)amino)cyclohexyl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Application Notes Validamycin A is the major analogue of a family of cyclitol disaccharides isolated from Streptomyces hygroscopicus var. limoneus by researchers at Takeda in 1970. Although commonly regarded as an aminoglycoside, validamycin shares little in common with conventional aminoglycosides such as streptomycin and gentamicin. Validamycin A is a potent antifungal agent and is used to control fungi in crop production. Validamycin A acts as a potent inhibitor of trehalase, an important enzyme in carbohydrate storage and ultilisation in fungi.Studies on validamycins, new antibiotics. I. Streptomyces hygroscopicus var. limoneus nov. var. validamycin - producing organism.
References Duncan J. Wardrop and Samanthi L. Waidyarachchi.,Nat. Prod. Rep., 2010, 27, 1431.
Smiles O[C@H]1[C@@H]([C@H](C[C@H](N[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])C=C2CO)[C@@H]1O)CO)O[C@]([C@@H]([C@@H](O)[C@@H]3O)O)([H])O[C@@H]3CO
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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Related Results

- API Standards of Validamycin
- Stable Isotopes of Validamycin
- Metabolites of Validamycin
- Impurities of Validamycin
- Glucuronides of Validamycin
- Intermediates of Validamycin

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