JNK-IN-8
INHIBITORS    
Availability: Available - Dispatch by : 22-Dec-2019 5:00 PM
CAT No. CS-CM-00202
Category Inhibitors
CAS 1410880-22-6
Mol. Weight 507.58 g/mol
Mol. Formula C29H29N7O2
View COA View MSDS
Product Description
Stock Status Available - Dispatch by : 22-Dec-2019 5:00 PM
Synonyms (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Application Notes Remarkably potent and selective covalent inhibitor of JNK (IC50 values 4.67 nM, 18.7 nM, and 0.98nM for JNK1/2/3, respectively). JNK-IN-8 inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue (EC50 values 486 nM and 338 nM for inhibition of c-Jun phosphorylation in HeLa and A375 cells, respectively). Useful as a pharmacological probe of JNK-dependent signal transduction
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


Have questions about this product or Require Pricing?
Let us help you.
Our automated system will send you a quote for your specific qty along with Discount, timelines or Stock status.

Stock Status   Bulk Quote   Required Pricing



Guaranteed Delivery
We ship worldwide through leading logistics partners.
Our shipment reaches you from our stock point closest to your country (US)


You may be also interested


Quality Assurance


c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated


Customer Reviews