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CAT No. CS-CM-00202
Category Inhibitors
CAS 1410880-22-6
Mol. Weight 507.58 g/mol
Mol. Formula C29H29N7O2
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Product Description
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Synonyms (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
Application Notes Remarkably potent and selective covalent inhibitor of JNK (IC50 values 4.67 nM, 18.7 nM, and 0.98nM for JNK1/2/3, respectively). JNK-IN-8 inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue (EC50 values 486 nM and 338 nM for inhibition of c-Jun phosphorylation in HeLa and A375 cells, respectively). Useful as a pharmacological probe of JNK-dependent signal transduction
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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NIST Calibrated