NRX 194204 - NRX 4204/ VTP 194204/ AGN 194204/ AGN 4204
Availability: For Exact delivery date, please contact
CAT No. CS-CM-00232
Category Inhibitors
CAS 220619-73-8
Mol. Weight 352.5 g/mol
Mol. Formula C24H32O2
View COA View MSDS
Product Description
Stock Status For Exact delivery date, please contact
Synonyms (2E,4E)-3-methyl-5-((1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)penta-2,4-dienoic acid
Application Notes Highly potent and specific RXR agonist (Kd values 0.4 nM, 3.6 nM, and 3.8 nM for RXRa, RXR, and RXR, respectively) devoid of any RAR activity (Kd values >30 M for RARa, RAR, and RAR). NRX 194204 blocked the ability of lipopolysaccharide and TNFa to induce the release of nitric oxide and IL6 and the degradation of IKBa in RAW264.7 macrophage-like cells. NRX194204 prevents carcinogenesis in both the lung and mammary gland, and enhances the ability of ligands for PPARs or cytotoxic drugs, including cisplatin and 5-flurouracil, to inhibit proliferation and induce apoptosis in breast and pancreatic cancer cell lines.
Pubchem Id 9863341
Smiles CC(=CC(=O)O)C=CC1CC1(C)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Have questions about this product or Require Pricing?
Let us help you.
Our automated system will send you a quote for your specific qty along with Discount, timelines or Stock status.

Stock Status   Required Pricing

Guaranteed Delivery
We ship worldwide through leading logistics partners.
Our shipment reaches you from our stock point closest to your country (US)

Quality Assurance

ISO 9001:2005
OHSAS 18001:2007
ISO 14001:2005
ISO 17034:2016
ISO/IEC 17025:2017
NIST Calibrated