NRX 194204 - NRX 4204/ VTP 194204/ AGN 194204/ AGN 4204
INHIBITORS    
Availability: Available - Dispatch by : 20-Dec-2019 5:00 PM
CAT No. CS-CM-00232
Category Inhibitors
CAS 220619-73-8
Mol. Weight 352.5 g/mol
Mol. Formula C24H32O2
View COA View MSDS
Product Description
Stock Status Available - Dispatch by : 20-Dec-2019 5:00 PM
Synonyms (2E,4E)-3-methyl-5-((1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)penta-2,4-dienoic acid
Application Notes Highly potent and specific RXR agonist (Kd values 0.4 nM, 3.6 nM, and 3.8 nM for RXRa, RXRß, and RXR, respectively) devoid of any RAR activity (Kd values >30 µM for RARa, RARß, and RAR). NRX 194204 blocked the ability of lipopolysaccharide and TNFa to induce the release of nitric oxide and IL6 and the degradation of IKBa in RAW264.7 macrophage-like cells. NRX194204 prevents carcinogenesis in both the lung and mammary gland, and enhances the ability of ligands for PPARs or cytotoxic drugs, including cisplatin and 5-flurouracil, to inhibit proliferation and induce apoptosis in breast and pancreatic cancer cell lines.
Pubchem Id 9863341
Smiles CC(=CC(=O)O)C=CC1CC1(C)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


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c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c5
NIST Calibrated


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