Sacubitrilat D4
Availability: In-Stock
Dispatch by : 16-Nov-2019 5:00 PM
CAT No. CS-O-16369
Category Stable Isotopes
Parent API Sacubitril
CAS 149709-44-4(Unlabeled)
Mol. Weight 387.46 mol/g
Mol. Formula C22H21D4NO5
Product Description
Stock Status In-Stock
Dispatch by : 16-Nov-2019 5:00 PM
Synonyms (2R,4S)-5-{[1,1'-biphenyl]-4-yl}-4-[3-carboxy(2,2,3,3-D4)propanamido]-2-methylpentanoic acid; Desethyl Sacubitril D4
Storage Conditions
Purity (%) >98
Application Notes Sacubitrilat D4 is the labelled, deuterated version of Sacubitrilatl which is an impurity in the synthesis of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);
Smileys O=C(C([2H])([2H])C([2H])([2H])C(O)=O)N[C@@H](C[C@@H](C)C(O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1
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The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

Quality Assurance

ISO 9001:2005
OHSAS 18001:2007
ISO 14001:2005
NIST Calibrated
Related Results

- API Standards of Sacubitril
- Stable Isotopes of Sacubitril
- Metabolites of Sacubitril
- Impurities of Sacubitril
- Glucuronides of Sacubitril
- Intermediates of Sacubitril

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