Dexamethasone Phosphate


Dexamethasone Phosphate is a Intermediate of Dexamethasone with CAS Registry No: 312-93-6
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CAT No. CS-T-52124
Category Intermediates
Parent API Dexamethasone
CAS 312-93-6
Mol. Weight 472.44 g/mol
Mol. Formula C22H30FO8P
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Synonyms (11β,16a)-9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione; 9-Fluoro-11β,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-Phosphate; Betnelan Phosphate; Dexamethasone 21-Dihydrogen Phosphate;
Storage Conditions -20°C Freezer, Under Inert Atmosphere
Purity (%) >98%
Melting Point (℃)176-178 
Solubility DMSO, Methanol
Appearance Off-White to Light Brown Solid
Application Notes A pro-drug of Dexamethasone , an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.
References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),
Pubchem Id 9400
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)(O)O)O)C)O)F)C
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy

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