Linsitinib
API STANDARDS    
Availability: Compound under re-stock / certification. Please enquire for exact delivery date
CAT No. CS-T-57272
Category API Standards
Parent API Linsitinib
CAS 867160-71-2
Mol. Weight 421.49 g/mol
Mol. Formula C26H33N5O
View COA View MSDS
Product Description
Stock Status Compound under re-stock / certification. Please enquire for exact delivery date
Synonyms 3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol
Storage Conditions For long term store at -20°C
Purity (%) >98%
Melting Point (℃)>175 
Solubility DMSO
Appearance Pale Yellow Solid
Application Notes Linsitinib is a small-molecule dual insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor. IGF-I receptor (IGF-IR) has been implicated in the promotion of tumorigenesis, metastasis and resistance to cancer therapies and thus Linsitinib may be a useful anticancer agent.
References Mulvihill, M.M.J. et al.: Fut. Med. Chem., 1, 1153 (2009); Flanigan, S.A. et al.: Clin. Cancer Res., 16, 5436 (2010); McKinley, E.T. et al.: Clin. Cancer Res., 17, 3332 (2011);
Smiles O[[email protected]@]1(C)C[[email protected]@H](C2=NC(C3=CC=C4C=CC(C5=CC=CC=C5)=NC4=C3)=C6C(N)=NC=CN62)C1
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy


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Related Results

- API Standards of Linsitinib
- Stable Isotopes of Linsitinib
- Metabolites of Linsitinib
- Impurities of Linsitinib
- Glucuronides of Linsitinib
- Intermediates of Linsitinib

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c1
ISO 9001:2005
c4
OHSAS 18001:2007
c5
ISO 14001:2005
c4
ISO 17034:2016
c5
ISO/IEC 17025:2017
c5
NIST Calibrated


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