Abemaciclib D5

Product Name Abemaciclib D5
Alternate Names Abemaciclib Stable Isotopes, Stable Isotopes of Abemaciclib
CAT No. CS-O-32774
CAS No. 1231929-97-7 (Unlabeled)
Category Stable Isotopes
Stock Enquire
Mol. Wt. 511.62 g/mol
Mol. For. C22H27D5F2N8
Hazardous This is not a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Abemaciclib
Therapeutic Anti-Cancer / Oncology
Smileys CC(N1C2=CC(C3=NC(NC4=CC=C(CN5CCN(C([2H])([2H])C([2H])([2H])[2H])CC5)C=N4)=NC=C3F)=CC(F)=C2N=C1C)C
Canonical Smiles CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F
Inchl InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)
IUPAC N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine
Controlled No
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What is the usage and chemical information of Abemaciclib D5 ?

Abemaciclib D5 is a chemical compound that is used in the treatment of breast cancer. It is a potent and selective inhibitor of cyclin-dependent kinase 4 and 6 (CDK4/6), which are enzymes involved in cell division. By inhibiting these enzymes, Abemaciclib D5 slows down the growth of cancer cells and prevents them from dividing and multiplying. The usage of Abemaciclib D5 is primarily for the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. It is generally administered orally, with the recommended dose being 150 mg twice daily. The dosage may vary depending on the patient's condition and response to treatment. Chemically, Abemaciclib D5 is a deuterated version of Abemaciclib, which means that it contains five atoms of deuterium. Deuterium is a stable isotope of hydrogen that has been used in the development of drugs to improve their pharmacokinetic properties, such as bioavailability, half-life, and metabolic stability. Abemaciclib D5 has been extensively studied in preclinical and clinical trials, and it has been shown to have a favorable safety profile. However, like any other drug, it may cause side effects, such as diarrhea, nausea, fatigue, and decreased appetite. Patients taking Abemaciclib D5 should be closely monitored by healthcare professionals to manage any adverse reactions.

Related Compounds

Abemaciclib Impurity 1 D12 | Abemaciclib Impurity 5 D5 | Abemaciclib D7 | Abemaciclib D10 | Abemaciclib Impurity 1 D5 | Abemaciclib D8 |

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